Zhao Gui-Yun, Deng Bo-Wen, Zhang Chong-Yu, Cui Yi-Da, Bi Jia-Yi, Zhang Guo-Gang
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
J Nat Med. 2018 Jan;72(1):246-251. doi: 10.1007/s11418-017-1141-2. Epub 2017 Oct 23.
Two new phenanthrene and 9, 10-dihydrophenanthrene derivatives (1-2) with six known congeners (3-8) were isolated from the extraction of stems of Dendrobium officinale. Compounds 1 and 2 were based on carbon skeleton in which phenanthrene and 9, 10-dihydrophenanthrene moiety were linked with a phenylpropane unit through a dioxane bridge, respectively. Their structures were determined by comprehensive NMR spectroscopic data, the absolute configuration of new compounds were determined by comparing their experimental and calculated ECD for the first time. All the compounds were investigated contains two cancer cell lines (HI-60, THP-1). All the isolates showed cytotoxicity, especially compound 4 showed markedly cytotoxic activities against HI-60 and THP-1 cell lines with IC values of 11.96 and 8.92 μM.
从铁皮石斛茎的提取物中分离出两种新的菲和9,10 - 二氢菲衍生物（1 - 2）以及六种已知的同系物（3 - 8）。化合物1和2基于碳骨架，其中菲和9,10 - 二氢菲部分分别通过二氧六环桥与一个苯丙烷单元相连。通过综合核磁共振光谱数据确定了它们的结构，首次通过比较新化合物的实验和计算ECD确定了其绝对构型。对所有研究的化合物进行了两种癌细胞系（HI - 60、THP - 1）的测试。所有分离物均显示出细胞毒性，尤其是化合物4对HI - 60和THP - 1细胞系表现出显著的细胞毒性活性，IC值分别为11.96和8.92 μM。
