School of Pharmacy, Zunyi Medical University, Zunyi 563000, China; Key Laboratory of Basic Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, China.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Fitoterapia. 2020 Jun;143:104586. doi: 10.1016/j.fitote.2020.104586. Epub 2020 Apr 2.
Two new dihydrophenanthrofurans (1 and 2) and two new bisbibenzyl derivatives (3 and 4) were isolated from the traditional Chinese medicinal plant Dendrobium nobile, along with four known compounds (5-8). The absolute configurations of compounds 1 and 4 were elucidated through extensive NMR and ECD spectroscopic analyses. New compounds showed no antimicrobial activity against four gram-positive bacterial strains and four gram-negative bacteria at the concentration of 1 mg/mL, but displayed significant cytotoxic activity against HepG2 human hepatic cell line with the IC values ranging from 1.25 μM to 19.47 μM.
从中国传统药用植物铁皮石斛中分离得到两种新的二氢菲并呋喃（1 和 2）和两种新的双芐基衍生物（3 和 4），以及四种已知化合物（5-8）。通过广泛的 NMR 和 ECD 光谱分析阐明了化合物 1 和 4 的绝对构型。新化合物在 1 mg/mL 的浓度下对四种革兰氏阳性菌和四种革兰氏阴性菌均没有抗菌活性，但对 HepG2 人肝母细胞瘤细胞系显示出显著的细胞毒性活性，IC 值范围为 1.25 μM 至 19.47 μM。
