Zhan Rui, Wang Zhi-Chong, Yin Ben-Lin, Liu Ying, Chen Ye-Gao
School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China.
School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China.
Chin J Nat Med. 2016 Aug;14(8):621-5. doi: 10.1016/S1875-5364(16)30073-5.
The present study was designed to identify bioactive compounds similar to those isolated from Dendrobium genus from its relative specie Eria bambusifolia. Compounds 1-10 were isolated and purified using silica gel, MCI CHP-20 gel, Sephadex LH-20, and Lichroprep RP-18 chromatography methods. Their structures were elucidated by means of extensive spectroscopic analyses. The cytotoxicity of these compounds against five human cancer cell lines was tested. Erathrins A and B (1 and 2) were new compounds, and compound 1 represented a novel carbon framework having a phenanthrene-phenylpropane unit with a dioxane moiety. Moreover, compound 1 showed selective cytotoxic activity against HL-60 cells (IC50 = 14.50 μmol·L(-1)). These results provided a basis for future development of these agents as anticancer lead compounds.
本研究旨在从其近缘物种毛竹叶毛兰中鉴定出与从石斛属植物中分离出的类似的生物活性化合物。采用硅胶、MCI CHP - 20凝胶、Sephadex LH - 20和Lichroprep RP - 18色谱方法分离纯化了化合物1 - 10。通过广泛的光谱分析阐明了它们的结构。测试了这些化合物对五种人类癌细胞系的细胞毒性。毛竹素A和B（1和2）是新化合物，化合物1代表一种具有菲 - 苯丙烷单元和二氧六环部分的新型碳骨架。此外，化合物1对HL - 60细胞表现出选择性细胞毒性活性（IC50 = 14.50 μmol·L(-1)）。这些结果为这些药物作为抗癌先导化合物的未来开发提供了依据。
