金花茶醇A - G，一类具有蛋白酪氨酸磷酸酶1B抑制作用的、类似巴里金醇的三萜类化合物，源自濒危观赏植物金花茶。
Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana.
作者信息
Xiong Juan, Wan Jiang, Ding Jie, Wang Pei-Pei, Ma Guang-Lei, Li Jia, Hu Jin-Feng
机构信息
Department of Natural Products Chemistry, School of Pharmacy, Fudan University , Shanghai 201203, People's Republic of China.
School of Chemical Engineering, Sichuan University of Science & Engineering , Zigong 643000, People's Republic of China.
出版信息
J Nat Prod. 2017 Nov 22;80(11):2874-2882. doi: 10.1021/acs.jnatprod.7b00241. Epub 2017 Oct 24.
Seven new naturally occurring barrigenol-like compounds, camellianols A-G (1-7), and 10 known triterpenoids were isolated from the twigs and leaves of the cultivated endangered ornamental plant Camellia crapnelliana. According to the ECD octant rule for saturated cyclohexanones, the absolute configurations of camellianols D (4) and E (5) were defined. The backbones of the remaining new isolates are assumed to have the same absolute configuration as compounds 4, 5, and harpullone (12). Compounds 2, 3, 9, 10, 13, and 16 exhibited inhibitory effects on the protein tyrosine phosphatase 1B (PTP1B) enzyme, with IC values less than 10 μM.
从栽培的濒危观赏植物杜鹃红山茶的嫩枝和叶片中分离出7种新的天然产原根二醇类化合物——茶醇A - G（1 - 7）以及10种已知的三萜类化合物。根据饱和环己酮的ECD八区规则，确定了茶醇D（4）和茶醇E（5）的绝对构型。假定其余新分离物的骨架与化合物4、5和哈普洛酮（12）具有相同的绝对构型。化合物2、3、9、10、13和16对蛋白酪氨酸磷酸酶1B（PTP1B）酶表现出抑制作用，IC值小于10 μM。
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