Li Wei, Qiu Qi, Sun Lin, Yue Ling, Wang Tao, Li Xia, Xiao Shifu
Alzheimer's Disease and Related Disorders Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Neuropsychiatr Dis Treat. 2017 Sep 14;13:2405-2410. doi: 10.2147/NDT.S145245. eCollection 2017.
Sex differences in Alzheimer's disease and mild cognitive impairment have been well recognized. However, sex differences in cognitive function and obesity in cognitively normal aging Chinese Han population have not attracted much attention.
The aim of this study was to investigate the relationship between sex, obesity, and cognitive function in an elderly Chinese population with normal cognitive function.
A total of 228 cognitively normal aging participants (males/females =93/135) entered this study. Their general demographic information (sex, age, and education) was collected by standardized questionnaire. Apolipoprotein E (APOE) genotype and serum lipid levels were measured. The Montreal Cognitive Assessment (MoCA) was used to assess participants' cognitive function.
The prevalence of obesity in elderly women (18/133, 13.5%) was significantly higher than that in men (5/92, 5.4%, =0.009). Regression analyses showed that obesity was associated with drinking alcohol (OR =13.695, =0.045) and triglyceride (OR =1.436, =0.048) in women and limited to low-density lipoprotein (OR =11.829, =0.023) in men. Women performed worse on the naming score for MoCA than men (<0.01). Stepwise linear regression analysis showed that education (=3.689, <0.001) and smoking (=2.031, =0.045) were related to the score of naming in female, while high-density lipoprotein (=-2.077, =0.041) was related to the score of naming in male; however, no correlation was found between body mass index and cognitive function in both male and female (>0.05).
Our finding suggests that there are significant sex differences in obesity and specific cognitive domains in aging Chinese Han population with normal cognitive function.
阿尔茨海默病和轻度认知障碍中的性别差异已得到充分认识。然而，认知功能正常的中国汉族老年人群中认知功能与肥胖的性别差异尚未引起太多关注。
本研究旨在调查认知功能正常的中国老年人群中性别、肥胖与认知功能之间的关系。
共有228名认知功能正常的老年参与者（男性/女性 = 93/135）进入本研究。通过标准化问卷收集他们的一般人口统计学信息（性别、年龄和教育程度）。测量载脂蛋白E（APOE）基因型和血脂水平。使用蒙特利尔认知评估量表（MoCA）评估参与者的认知功能。
老年女性肥胖患病率（18/133，13.5%）显著高于男性（5/92，5.4%，P = 0.009）。回归分析显示，肥胖在女性中与饮酒（OR = 13.695，P = 0.045）和甘油三酯（OR = 1.436，P = 0.048）相关，在男性中仅限于低密度脂蛋白（OR = 11.829，P = 0.023）。女性在MoCA的命名得分上比男性差（P < 0.01）。逐步线性回归分析显示，教育程度（β = 3.689，P < 0.001）和吸烟（β = 2.031，P = 0.045）与女性命名得分相关，而高密度脂蛋白（β = -2.077，P = 0.041）与男性命名得分相关；然而，男性和女性的体重指数与认知功能均无相关性（P > 0.05）。
我们的研究结果表明，认知功能正常的中国汉族老年人群在肥胖和特定认知领域存在显著的性别差异。
