Bayer Urike, Likar Rudolf, Pinter Georg, Stettner Haro, Demschar Susanne, Trummer Brigitte, Neuwersch Stefan, Glazachev Oleg, Burtscher Martin
Department of Geriatrics, Klinikum Klagenfurt, Klagenfurt, Austria.
Department of Anesthesiology and Intensive Care Medicine, Klinikum Klagenfurt, Klagenfurt, Austria.
Alzheimers Dement (N Y). 2017 Feb 8;3(1):114-122. doi: 10.1016/j.trci.2017.01.002. eCollection 2017 Jan.
Intermittent hypoxic-hyperoxic training (IHHT) may complement a multimodal training intervention (MTI) for improving cognitive function and exercise tolerance in geriatric patients.
Thirty-four patients (64-92 years) participated in this randomized controlled trial. Before and after the 5- to 7-week intervention period (MTI + IHHT vs. MTI + ambient air), cognitive function was assessed by the Dementia-Detection Test (DemTect) and the Sunderland Clock-Drawing Test (CDT), and functional exercise capacity by the total distance of the 6-Minute Walk Test (6MWT).
DemTect and CDT indicated significantly larger improvements after MTI + IHHT (+16.7% vs. -0.39%, < .001) and (+10.7% vs. -8%, = .031) which was also true for the 6MWT (+24.1% vs. +10.8%, = .021).
IHHT turned out to be easily applicable to and well tolerated by geriatric patients up to 92 years. IHHT contributed significantly to improvements in cognitive function and functional exercise capacity in geriatric patients performing MTI.
间歇性低氧-高氧训练（IHHT）可能是多模式训练干预（MTI）的补充手段，有助于改善老年患者的认知功能和运动耐量。
34名年龄在64至92岁之间的患者参与了这项随机对照试验。在为期5至7周的干预期（MTI + IHHT组与MTI + 常氧组）前后，通过痴呆症检测测试（DemTect）和桑德兰钟表绘制测试（CDT）评估认知功能，并通过6分钟步行测试（6MWT）的总距离评估功能运动能力。
DemTect和CDT显示，MTI + IHHT组在干预后的改善幅度显著更大（分别为+16.7%对 -0.39%， <.001）和（+10.7%对 -8%， = .031），6MWT也是如此（+24.1%对 +10.8%， = .021）。
结果表明，IHHT很容易应用于92岁以下的老年患者，且耐受性良好。在进行MTI的老年患者中，IHHT对认知功能和功能运动能力的改善有显著贡献。
