一项关于听力治疗以减少认知衰退的随机可行性初步试验：老年人衰老与认知健康评估初步研究的结果。
A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study.
作者信息
Deal Jennifer A, Albert Marilyn S, Arnold Michelle, Bangdiwala Shrikant I, Chisolm Theresa, Davis Sonia, Eddins Ann, Glynn Nancy W, Goman Adele M, Minotti Melissa, Mosley Thomas, Rebok George W, Reed Nicholas, Rodgers Elizabeth, Sanchez Victoria, Sharrett A Richey, Coresh Josef, Lin Frank R
机构信息
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
出版信息
Alzheimers Dement (N Y). 2017 Jun 21;3(3):410-415. doi: 10.1016/j.trci.2017.06.003. eCollection 2017 Sep.
INTRODUCTION
Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults.
METHODS
A 40-person (aged 70-84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254.
RESULTS
The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to -1.29 standard deviation [SD] units; lower scores better) and memory (mean of -0.10 SD to 0.38 SD).
DISCUSSION
ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.
引言
听力损失（HL）很常见，且与认知能力下降和痴呆症独立相关。此前从未有过随机试验来检验HL治疗是否能减少老年人的认知能力下降。
方法
在马里兰州华盛顿县进行了一项有40人（年龄在70 - 84岁之间）参与的试点研究。参与者按1:1随机分为接受最佳听力实践或成功老龄化干预两组，并随访6个月。临床试验注册号：NCT02412254。
结果
老年人衰老与认知健康评估试点（ACHIEVE - P）研究表明，在招募、留存参与者以及实施干预措施方面具有可行性，且未出现与治疗相关的不良事件。在感知听力障碍（平均从0.11降至 - 1.29标准差[SD]单位；分数越低越好）和记忆力（平均从 - 0.10 SD升至0.38 SD）方面观察到了听力干预的明显疗效信号。
讨论
ACHIEVE - P为全面的ACHIEVE试验（N = 850，2017年11月开始招募）奠定了基础，这是第一项确定最佳听力实践（与成功老龄化相比）干预措施对减少HL老年人认知能力下降疗效的随机试验。
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