2017年丹麦出现对头孢曲松耐药且对阿奇霉素中度耐药的多重耐药感染。
Multidrug-resistant infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017.
作者信息
Terkelsen David, Tolstrup Jacob, Johnsen Camilla Hundahl, Lund Ole, Larsen Helle Kiellberg, Worning Peder, Unemo Magnus, Westh Henrik
机构信息
Department of Clinical Microbiology, Hvidovre Hospital, Copenhagen, Denmark.
These authors contributed equally to the work.
出版信息
Euro Surveill. 2017 Oct;22(42). doi: 10.2807/1560-7917.ES.2017.22.42.17-00659.
Abstract
We describe a multidrug-resistant infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.
摘要
我们描述了2017年在丹麦一名异性恋男性中发生的对头孢曲松耐药且对阿奇霉素中介耐药的多重耐药感染。对菌株GK124进行全基因组测序，确定其属于MSLT ST1903、NG-MAST ST1614，并且鉴定出了所有相关耐药决定因素，包括先前在耐头孢曲松淋病奈瑟菌菌株中描述过的类似penA耐药突变。尽管使用0.5克头孢曲松加2克阿奇霉素治疗取得了成功，但提高对威胁推荐的双重疗法的淋病奈瑟菌菌株传播的认识至关重要。
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