Department of Laboratory Medicine, the Second Xiangya Hospital of Central South University, Changsha, People's Republic of China.
National Health Commission Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Emerg Microbes Infect. 2019;8(1):1546-1549. doi: 10.1080/22221751.2019.1681242.
The growing multidrug-resistant is a serious global threat to gonococcal therapy. During 2017-2018, we identified a rare multidrug-resistant (ceftriaxone and azithromycin) strain (GC250) and four strains (GC185, GC195, GC196 and GC249) with both resistance to ceftriaxone and decreased susceptibility to azithromycin. All strains belonged to NG-STAR ST1143, including the mosaic -60.001, which is closely related to ceftriaxone resistance. The characterization of antimicrobial resistance (AMR) determinants and phylogenetic analysis showed these five strains were closely related to internationally spreading ceftriaxone-resistant FC428, but with higher azithromycin MIC. Findings here demonstrated that this clone not only initiated clonal expansion in China, but acquired azithromycin resistance.
不断增加的耐多药淋病奈瑟菌对淋球菌治疗构成严重的全球威胁。在 2017-2018 年期间，我们发现了一种罕见的耐多药（头孢曲松和阿奇霉素）菌株（GC250）和 4 株对头孢曲松耐药且对阿奇霉素敏感性降低的菌株（GC185、GC195、GC196 和 GC249）。所有菌株均属于 NG-STAR ST1143，包括与头孢曲松耐药密切相关的马赛克-60.001。这些菌株的抗菌药物耐药性（AMR）决定因素和系统发育分析表明，这 5 株菌与国际传播的头孢曲松耐药淋病奈瑟菌 FC428 密切相关，但对阿奇霉素的 MIC 值更高。研究结果表明，该克隆不仅在中国引发了克隆扩张，而且获得了对阿奇霉素的耐药性。
