儿童发育性阅读障碍的遗传和环境风险因素：过去十年的系统综述
Genetic and environmental risk factors for developmental dyslexia in children: systematic review of the last decade.
作者信息
Becker Natalia, Vasconcelos Mailton, Oliveira Vanessa, Santos Fernanda Caroline Dos, Bizarro Lisiane, Almeida Rosa M M De, Salles Jerusa Fumagalli De, Carvalho Maria Raquel Santos
机构信息
a Cognitive Neuropsychology Research Center (Neurocog), Department of Developmental and Personality Psychology , Post-Graduation Program in Psychology, Institute of Psychology, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre , Rio Grande do Sul , Brazil.
b Experimental Psychology, Neuroscience and Behavior Lab, Department of Developmental and Personality Psychology , Post-Graduation Program in Psychology, Institute of Psychology, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre , Rio Grande do Sul , Brazil.
出版信息
Dev Neuropsychol. 2017;42(7-8):423-445. doi: 10.1080/87565641.2017.1374960. Epub 2017 Oct 25.
Despite advances in the characterization of developmental dyslexia (DD), several questions regarding the interplay between DD-susceptibility genes and environmental risk factors remain open. This systematic review aimed at answering the following questions: What has been the impact of new resources on the knowledge about DD? Which questions remain open? What is the investigative agenda for the short term? Forty-six studies were analyzed. Despite the growing literature on DD candidate genes, most studies have not been replicated. We found large effects on causative genes and smaller environmental contributions, involving maternal smoking during pregnancy, SES and the DYX1C1-1259C/G marker. Implications are discussed.
尽管在发育性阅读障碍（DD）的特征描述方面取得了进展，但关于DD易感基因与环境风险因素之间相互作用的几个问题仍未解决。本系统综述旨在回答以下问题：新资源对DD知识有何影响？哪些问题仍未解决？短期的研究议程是什么？分析了46项研究。尽管关于DD候选基因的文献越来越多，但大多数研究尚未得到重复验证。我们发现致病基因的影响很大，而环境因素的影响较小，涉及孕期母亲吸烟、社会经济地位（SES）和DYX1C1-1259C/G标记。文中对相关影响进行了讨论。
Zotero 插件