Fan Jin-Hu, Zhang Yu-Qing, Shi Su-Sheng, Chen Yuan-Jia, Yuan Xing-Hua, Jiang Li-Ming, Wang Shao-Ming, Ma Li, He Yu-Tong, Feng Chang-Yan, Sun Xi-Bin, Liu Qing, Deloso Katrina, Chi Yihebali, Qiao You-Lin
Department of Cancer Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College.
Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College.
Oncotarget. 2017 May 3;8(42):71699-71708. doi: 10.18632/oncotarget.17599. eCollection 2017 Sep 22.
Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients.
This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) retrospective study which collected GEP-NEN patients' information in tertiary referral hospitals. All 2010 inpatient GEP-NEN cases with confirmed pathology in the selected hospitals were included. The primary GEP-NEN sites were measured and the epidemiological and clinical information of each tumor site were compared.
The most common primary sites for GEP-NEN were the pancreas (31.5%) and rectum (29.6%), followed by the cardia (11.6%) and body (15.4%) of stomach. Small intestinal and colonic NENs took up a relatively small proportion of all patients. Pancreatic and rectal NENs, rather than cardiac and gastric body NENs, tended to be found in younger (<0.001), female (<0.001), urban (<0.001) residents with a higher education level (P=0.032) and were also diagnosed at earlier stage (<0.001) and lower grade (<0.001). Surgery remained the primary treatment method in all groups.
More studies on the commonality and heterogeneity of GEP-NENs are warranted to improve diagnosis efficiencies and treatment outcomes.
关于亚洲患者，尤其是中国患者的胃肠胰神经内分泌肿瘤（GEP-NENs）的代表性数据很少。本研究旨在建立中国患者的GEP-NENs概况。
这是一项基于医院的全国性多中心10年（2001 - 2010年）回顾性研究，收集了三级转诊医院中GEP-NEN患者的信息。纳入了所选医院中所有2010年经病理确诊的住院GEP-NEN病例。测量了GEP-NEN的主要发病部位，并比较了每个肿瘤部位的流行病学和临床信息。
GEP-NEN最常见的原发部位是胰腺（31.5%）和直肠（29.6%），其次是胃贲门（11.6%）和胃体（15.4%）。小肠和结肠NENs在所有患者中所占比例相对较小。胰腺和直肠NENs，而非贲门和胃体NENs，往往在年龄较小（<0.001）、女性（<0.001）、城市居民（<0.001）、受教育程度较高（P = 0.032）的人群中发现，并且诊断时分期较早（<0.001）、分级较低（<0.001）。手术仍然是所有组的主要治疗方法。
有必要对GEP-NENs的共性和异质性进行更多研究，以提高诊断效率和治疗效果。
