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Anthropol Med. 2005 Dec;12(3):239-54. doi: 10.1080/13648470500291360.
2
Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study.柬埔寨恶性疟原虫疟疾中双氢青蒿素-哌喹耐药性:一项多地点前瞻性队列研究。
Lancet Infect Dis. 2016 Mar;16(3):357-65. doi: 10.1016/S1473-3099(15)00487-9. Epub 2016 Jan 8.
3
Rapid diagnostic tests for malaria and health workers' adherence to test results at health facilities in Zambia.赞比亚医疗机构中疟疾快速诊断检测及卫生工作者对检测结果的遵循情况
Malar J. 2014 May 2;13:166. doi: 10.1186/1475-2875-13-166.
4
The politics and anti-politics of the global fund experiment: understanding partnership and bureaucratic expansion in Uganda.全球基金实验的政治与反政治:理解乌干达的伙伴关系与官僚扩张
Med Anthropol. 2014;33(3):206-22. doi: 10.1080/01459740.2013.796941.
5
The Affordable Medicines Facility-malaria--a success in peril.《平价药品机制-疟疾》:岌岌可危的成功典范。
Malar J. 2012 Nov 8;11:370. doi: 10.1186/1475-2875-11-370.
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Piloting the Affordable Medicines Facility-malaria: what will success look like?《平价药品机制 - 疟疾项目》先导计划:成功的标准是什么?
Bull World Health Organ. 2012 Jun 1;90(6):452-60. doi: 10.2471/BLT.11.091199. Epub 2012 Feb 3.
7
Some lessons for the future from the Global Malaria Eradication Programme (1955-1969).从全球疟疾根除计划(1955-1969 年)中吸取的未来教训。
PLoS Med. 2011 Jan 25;8(1):e1000412. doi: 10.1371/journal.pmed.1000412.
8
Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia.青蒿琥酯-甲氟喹联合疗法治疗柬埔寨南部非复杂性恶性疟原虫疟疾失败。
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The evolution of drug-resistant malaria.耐药性疟疾的演变。
Trans R Soc Trop Med Hyg. 2009 Apr;103 Suppl 1(Suppl 1):S11-4. doi: 10.1016/j.trstmh.2008.11.002. Epub 2008 Dec 12.
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Evidence of artemisinin-resistant malaria in western Cambodia.柬埔寨西部出现青蒿素耐药性疟疾的证据。
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抗疟药流通的社会文化复杂性:柬埔寨三个农村偏远社区的民族志研究。

Social and cultural complexities of anti-malarial drug circulation: an ethnographic investigation in three rural remote communes of Cambodia.

机构信息

Durham University, Durham, UK.

Institute de Recherche pour le Développement (IRD), P.O.Box 591, Phnom Penh, Cambodia.

出版信息

Malar J. 2017 Oct 25;16(1):428. doi: 10.1186/s12936-017-2082-7.

DOI:10.1186/s12936-017-2082-7
PMID:29070076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5657070/
Abstract

BACKGROUND

Anti-malarial medicine has a central role in malaria case management in Cambodia. It is, therefore, essential to study how anti-malarial drugs are distributed and consumed. This study aims to understand the socio-cultural complexity of anti-malarial drugs provision and usage practices.

METHODS

Semi-structured interviews and observation were conducted in Cambodia at the communal, provincial, and national levels from January 2014 to January 2015. Health ministers, non-governmental officers, anti-malarial medicines distributors, village malaria volunteers and malaria patients were interviewed.

FINDINGS

The findings show that artemisinin-based combination therapy (ACT) flows into unregulated outlets, and was sold without any diagnostic tests. Affordable Medicines Facility for malaria scheme (AMFm) cannot drive ineffective anti-malarial medicines out of the market because ACT is still more expensive due to price absortion by private and public providers. Malaria patients might not consume ACT because of patients' notions of 'Korp', and pharmaceutical and parasitic familiarity. The findings reflect that neither public nor private institutions have the capacity and resources to control the flow of ACT from going into the unlicensed sector. They do not have the ability to ensure that ACT is consumed after a positive rapid diagnostic test.

CONCLUSIONS

With a weak regulation system and ailing public health infrastructure, pharmaceutical-neoliberal mechanism like AMFm is not an effective means to eradicate any forms of malaria. Therefore, horizontal programmes, such as public health infrastructure improvement, and population participation must be implemented. Ethnical responsibilities of medical practitioners must be enforced and be included into the national curriculum. The awareness of drug resistance must be implemented at all levels.

摘要

背景

抗疟药物在柬埔寨疟疾病例管理中起着核心作用。因此,研究抗疟药物的分布和使用情况至关重要。本研究旨在了解抗疟药物供应和使用实践中的社会文化复杂性。

方法

2014 年 1 月至 2015 年 1 月,在柬埔寨的社区、省和国家各级进行了半结构式访谈和观察。访谈了卫生部长、非政府官员、抗疟药物经销商、乡村疟疾志愿者和疟疾患者。

结果

研究结果表明,青蒿素类复方疗法(ACT)流入不受监管的渠道,未经任何诊断检测就被出售。负担得起的抗疟药品采购机制(AMFm)无法将无效的抗疟药物逐出市场,因为由于私人和公共供应商的价格吸收,ACT 仍然更昂贵。疟疾患者可能不会服用 ACT,因为患者有“Korp”的观念,以及对药物和寄生虫的熟悉。研究结果反映出,公共和私人机构都没有能力和资源来控制 ACT 从合法渠道流向非法渠道。他们也没有能力确保在进行快速诊断检测呈阳性后使用 ACT。

结论

由于监管制度薄弱和公共卫生基础设施不佳,像 AMFm 这样的制药新自由主义机制并不是消除任何形式疟疾的有效手段。因此,必须实施横向计划,如改善公共卫生基础设施和提高人口参与度。必须执行医务人员的职业道德责任,并将其纳入国家课程。必须在各级提高对抗药性的认识。