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2005年至2010年在土耳其选定的两个奶牛场进行的关于接种牛疱疹病毒1型糖蛋白E缺失标记疫苗的长期研究。

Long-term study (2005-2010) on the vaccination with BoHV-1 glycoprotein E-deleted marker vaccine in selected two dairy herds in Turkey.

作者信息

Alkan Feray, Bilge-Dagalp S, Karapınar Z, Timurkan M O, Coskun N, Burgu I

机构信息

Faculty of Veterinary Medicine, Department of Virology, Ankara University, Ankara, Turkey.

Faculty of Veterinary Medicine, Department of Virology, Balıkesir University, Balıkesir, Turkey.

出版信息

Trop Anim Health Prod. 2018 Feb;50(2):353-363. doi: 10.1007/s11250-017-1440-3. Epub 2017 Oct 25.

Abstract

A follow-up study from 2005 to 2010 was carried out in two herds where eradication programme for the bovine herpes virus-1 (BoHV-1) infection depends on the vaccination with inactivated glycoprotein E-deleted vaccine that was started in 2001 following the vaccination with inactivated conventional vaccine between 1999 and 2001. For serological screening, a total of 12,976 sera sampled over several sampling times approximately 6 months of interval during 5 years (2005-2010) were tested for glycoprotein E (gE)- and glycoprotein B-specific antibodies using ELISA. According to the serological evidence, the long-term persistence of BoHV-1 antibodies, success of marker vaccine, first vaccination time of the calves in herds regularly vaccinated, etc. were discussed in this paper. In conclusion, the vaccination programme using gE (-) marker vaccines, with making efforts to prevent the other factors about transmission of infection, was suggested for the eradication of BoHV-1 infection in Turkey as many EU countries. This is the first report on the BoHV-1 eradication programme in some dairy cattle in Turkey.

摘要

2005年至2010年,在两个牛群中开展了一项随访研究,这两个牛群针对牛疱疹病毒1型(BoHV-1)感染的根除计划依赖于接种灭活的缺失糖蛋白E疫苗,该疫苗接种始于2001年,此前在1999年至2001年期间接种了灭活的常规疫苗。为了进行血清学筛查,在5年(2005 - 2010年)期间,每隔约6个月在多个采样时间点采集的总共12976份血清样本,使用酶联免疫吸附测定法(ELISA)检测了糖蛋白E(gE)和糖蛋白B特异性抗体。根据血清学证据,本文讨论了BoHV-1抗体的长期持续性、标记疫苗的成效、定期接种牛群中犊牛的首次接种时间等问题。总之,与许多欧盟国家一样,建议在土耳其采用使用gE(-)标记疫苗的接种计划,并努力预防感染传播的其他因素,以根除BoHV-1感染。这是关于土耳其一些奶牛BoHV-1根除计划的首份报告。

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