氟喹诺酮类药物与跟腱疾病风险：被忽视并发症的最新情况
Fluoroquinolones and the Risk of Achilles Tendon Disorders: Update on a Neglected Complication.
作者信息
Godoy-Santos Alexandre Leme, Bruschini Homero, Cury Jose, Srougi Miguel, de Cesar-Netto Cesar, Fonseca Lucas F, Maffulli Nicola
机构信息
Department of Orthopaedics and Traumatology, University of São Paulo, São Paulo, São Paulo, Brazil.
Department of Urology, University of São Paulo, São Paulo, São Paulo, Brazil.
出版信息
Urology. 2018 Mar;113:20-25. doi: 10.1016/j.urology.2017.10.017. Epub 2017 Oct 23.
OBJECTIVE
To evaluate the current evidence and to identify associated risk factors that increase the incidence of this complication. Fluoroquinolone (FQ) has been considered the first-line therapy for uncomplicated urinary infections. FQ has been associated with Achilles tendon disorders, especially during the first month of treatment.
METHODS
Data sources searched included PubMed, MEDLINE, and Scopus from January 1988 to June 2017.
RESULTS
A total of 79 articles were used, with ciprofloxacin representing the most common drug.
CONCLUSION
We found that male gender, advanced age, normal body mass index, chronic renal failure, and concurrent use of corticosteroids increase the risk of Achilles tendon disorders.
目的
评估现有证据并确定增加该并发症发生率的相关危险因素。氟喹诺酮（FQ）一直被视为单纯性泌尿系统感染的一线治疗药物。FQ与跟腱疾病有关，尤其是在治疗的第一个月。
方法
检索的数据源包括1988年1月至2017年6月期间的PubMed、MEDLINE和Scopus。
结果
共使用了79篇文章，其中环丙沙星是最常用的药物。
结论
我们发现男性、高龄、正常体重指数、慢性肾衰竭以及同时使用皮质类固醇会增加跟腱疾病的风险。
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