人层粘连蛋白B2基因的限制性片段长度多态性及连锁关系
RFLPs and linkage relationships of the human laminin B2 gene.
作者信息
Nishimura D, Buetow K H, Yamada Y, Murray J C
机构信息
Department of Pediatrics, University of Iowa, Iowa City 52242.
出版信息
Genomics. 1988 Nov;3(4):393-5. doi: 10.1016/0888-7543(88)90134-6.
RFLPs for laminin B2 (LAMB2) are reported. These RFLPs were used to study the linkage relationships of LAMB2 to four other genes on lq: Duffy (FY), renin (REN), decay accelerating factor (DAF), and complement receptor 2 (CR2). Multipoint linkage analysis placed LAMB2 between FY and the cluster including REN, DAF, and CR2. This provides a useful bridging polymorphic marker on lq and establishes significant linkage of LAMB2 to FY (theta = 3.23, z = 3.85) and REN (theta = 0.17, z = 4.88).
已报道层粘连蛋白B2（LAMB2）的限制性片段长度多态性（RFLP）。这些RFLP被用于研究LAMB2与1号染色体长臂上其他四个基因的连锁关系：达菲血型（FY）、肾素（REN）、衰变加速因子（DAF）和补体受体2（CR2）。多点连锁分析将LAMB2定位在FY和包括REN、DAF及CR2的基因簇之间。这在1号染色体长臂上提供了一个有用的桥接多态性标记，并确立了LAMB2与FY（θ = 3.23，z = 3.85）和REN（θ = 0.17，z = 4.88）的显著连锁。
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