Elliott R W, Barlow D, Hogan B L
In Vitro Cell Dev Biol. 1985 Aug;21(8):477-84. doi: 10.1007/BF02620837.
We have used cDNA clones for the B1 and B2 subunits of laminin to find restriction fragment length DNA polymorphisms for the genes encoding these polypeptides in the mouse. Three alleles were found for LamB2 and two for LamB1 among the inbred mouse strains. The segregation of these polymorphisms among recombinant inbred strains showed that these genes are tightly linked in the central region of mouse Chromosome 1 between Sas-1 and Ly-m22, 7.4 +/- 3.2 cM distal to the Pep-3 locus. There is no evidence in the mouse for pseudogenes for these proteins.
我们利用层粘连蛋白B1和B2亚基的cDNA克隆，在小鼠中寻找编码这些多肽的基因的限制性片段长度DNA多态性。在近交系小鼠品系中，发现了层粘连蛋白B2基因的三个等位基因和层粘连蛋白B1基因的两个等位基因。这些多态性在重组近交系中的分离表明，这些基因紧密连锁于小鼠1号染色体的中央区域，位于Sas-1和Ly-m22之间，距离Pep-3位点远端7.4±3.2厘摩。在小鼠中没有证据表明存在这些蛋白质的假基因。
