Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Surrey Sleep Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health and Medical Science, University of Surrey, Guildford, United Kingdom.
Front Neural Circuits. 2017 Oct 12;11:74. doi: 10.3389/fncir.2017.00074. eCollection 2017.
The process of neurogenesis has been demonstrated to occur throughout life in the subgranular zone (SGZ) of the hippocampal dentate gyrus of several mammals, including humans. The basal rate of adult hippocampal neurogenesis can be altered by lifestyle and environmental factors. In this perspective review, the evidence for sleep as a modulator of adult hippocampal neurogenesis is first summarized. Following this, the impacts of sleep and sleep disturbances on hippocampal-dependent functions, including learning and memory, and depression are critically evaluated. Finally, we postulate that the effects of sleep on hippocampal-dependent functions may possibly be mediated by a change in adult hippocampal neurogenesis. This could provide a route to new treatments for cognitive impairments and psychiatric disorders.
神经发生过程已被证明在包括人类在内的几种哺乳动物的海马齿状回颗粒下区（SGZ）中终生发生。成年海马神经发生的基础速率可以通过生活方式和环境因素改变。在本观点综述中，首先总结了睡眠作为成年海马神经发生调节剂的证据。在此之后，批判性地评估了睡眠和睡眠障碍对包括学习和记忆以及抑郁在内的海马依赖性功能的影响。最后，我们推测睡眠对海马依赖性功能的影响可能是通过成年海马神经发生的变化来介导的。这可能为认知障碍和精神障碍的新治疗方法提供途径。
