Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Curr Drug Targets. 2018;19(16):1897-1904. doi: 10.2174/1389450118666171027111050.
Recently, a great interest has been paid to the development of hybrid proteininorganic nanoparticles (NPs) for tissue engineering applications to combine the merits of both inorganic and protein nanocarriers.
This short review primarily discusses the most important advances in the application of the hybrids of proteins (gelatin, zein, silk fibroin,….etc) with inorganic NPs (calcium phosphate NPs, cadmium QDs, carbon nanotubes,…etc) in tissue engineering.
Various strategies that have been utilized for the preparation of protein-functionalized inorganic NPs are discussed. Nanocomposite films, electrospun nanofibrous scaffolds, nanostructured colloidal composite gels and nanocomposite lyophilized sponges are among the most common platforms of protein-inorganic nanohybrid formulations used in regenerative medicine.
protein-inorganic nanohybrids could serve as promising platforms for different biomedical applications including bone and cartilage tissue regeneration, imaging of engineered tissues, development of antithrombogenic implant biomaterials and anti-bacterial wound dressing as well.
近来，人们对开发用于组织工程应用的混合蛋白-无机纳米粒子（NPs）产生了浓厚的兴趣，以期结合无机和蛋白纳米载体的优点。
本文主要讨论了将蛋白（明胶、玉米醇溶蛋白、丝素蛋白等）与无机 NPs（磷酸钙 NPs、碲化镉 QDs、碳纳米管等）的混合物应用于组织工程的重要进展。
讨论了用于制备蛋白功能化无机 NPs 的各种策略。在再生医学中，用于组织工程的蛋白-无机纳米杂化制剂的最常见平台包括纳米复合膜、静电纺丝纳米纤维支架、纳米结构胶体复合凝胶和纳米复合冻干海绵。
蛋白-无机纳米杂化物可用作有前途的平台，用于多种生物医学应用，包括骨和软骨组织再生、工程组织成像、抗血栓植入生物材料和抗菌伤口敷料的开发等。
