Department of Education and Obesity Treatment and Metabolic Disorders, Poznań University of Medical Sciences, Poznań, Poland.
Eur Rev Med Pharmacol Sci. 2017 Oct;21(19):4379-4385.
To evaluate osteoprotegerin serum concentration (and compare with healthy controls), to estimate the relationship between serum osteoprotegerin and lipid parameters, insulin resistance, and selected inflammatory factors, and to assess the relationship between osteoprotegerin and intima media thickness in patients with metabolic syndrome.
A total of 70 individuals aged 18-65 years with metabolic syndrome were enrolled. Anthropometric parameters, including body weight, body mass index, waist circumference, and waist-hip ratio, were assessed. The relative and absolute fat tissue contents were evaluated. Serum glucose, insulin, osteoprotegerin, C-reactive protein, and lipid profile were determined. Insulin resistance was calculated using Homeostasis Model Assessment. Intima media complex thickness was evaluated in each participant.
No significant differences were observed between patients and the controls with respect to lipid and carbohydrate profiles. Osteoprotegerin was significantly elevated in metabolic syndrome patients compared to the controls. Both C-reactive protein serum concentration and insulin resistance increased in the metabolic syndrome patients. Significant positive correlations between osteoprotegerin serum concentration and body mass index, waist-hip ratio, C-reactive protein serum concentration, and insulin resistance, were documented in patients with metabolic syndrome.
Patients with metabolic syndrome have increased osteoprotegerin serum levels than healthy individuals. Osteoprotegerin plays an important role in the development of arteriosclerosis, and the effect of osteoprotegerin on intima media thickness strongly depends on the extent of the arteriosclerotic changes that occur in metabolic syndrome.
评估血清护骨素浓度（并与健康对照组进行比较），评估血清护骨素与血脂参数、胰岛素抵抗和选定的炎症因子之间的关系，并评估代谢综合征患者护骨素与内膜中层厚度之间的关系。
共纳入 70 名年龄在 18-65 岁之间的代谢综合征患者。评估了体重、体重指数、腰围和腰臀比等人体测量参数。评估了相对和绝对脂肪组织含量。测定了血清葡萄糖、胰岛素、护骨素、C 反应蛋白和血脂谱。使用稳态模型评估计算胰岛素抵抗。评估了每位参与者的内膜中层复合体厚度。
与对照组相比，代谢综合征患者的血脂和碳水化合物谱无显著差异。与对照组相比，代谢综合征患者的护骨素明显升高。代谢综合征患者的 C 反应蛋白血清浓度和胰岛素抵抗均升高。在代谢综合征患者中，护骨素血清浓度与体重指数、腰臀比、C 反应蛋白血清浓度和胰岛素抵抗之间存在显著正相关。
代谢综合征患者的护骨素血清水平高于健康个体。护骨素在动脉硬化的发展中起重要作用，护骨素对内膜中层厚度的影响强烈取决于代谢综合征中发生的动脉粥样硬化变化的程度。
