Department of Cardiology, Second People's Hospital of Chengdu, Chengdu, China.
Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Sci Rep. 2019 Nov 1;9(1):15838. doi: 10.1038/s41598-019-52132-6.
This study aimed to assess the prevalence and related factors of obesity-related hypertension among adults aged 40 to 79 years in Southwest China. From September 2013 to March 2014, a multi-stage, stratified sampling method was conducted on 10,589 people aged 40 to 79 years and living in Chengdu and Chongqing investigated by using a questionnaire and performing physical and biochemical measurements. The prevalence of obesity-related hypertension and hypertension overall (systolic ≥130 mmHg and/or diastolic ≥80 mmHg or treated hypertension) was 22.8% and 57.4%, respectively, among all participants. For obesity-related hypertension, the prevalence was higher in women than in men (24.7% versus 19.4%, p < 0.001). For people in the age ranges of 40-49, 50-59, 60-69, and ≥70, the prevalence of obesity-related hypertension were 11.8%, 22.6%, 30.7%, and 36.6%, respectively. Participants with obesity-related hypertension as opposed to those with non-obesity-related hypertension had a higher prevalence of hypertriglyceridemia, high low-density lipoprotein cholesterolemia, diabetes, and hyperuricemia (all p < 0.05). Multivariate logistic regression analysis showed that age, female gender, current smoking, hypertriglyceridemia, diabetes and family history of hypertension were all positively correlated with obesity-related hypertension, whereas higher education level and having spouse were negatively correlated with obesity-related hypertension. The prevalence of obesity-related hypertension was high among adults aged 40 to 79 years in Southwest China. Cardiometabolic abnormalities among participants with obesity-related hypertension were more serious and frequently present than in those with non-obesity-related hypertension. Aggressive and holistic strategies aiming at the prevention and treatment of obesity-related hypertension are needed.
本研究旨在评估中国西南地区 40 至 79 岁成年人中肥胖相关性高血压的患病率及其相关因素。2013 年 9 月至 2014 年 3 月，采用多阶段、分层抽样方法，对居住在成都和重庆的 10589 名 40 至 79 岁成年人进行问卷调查和体格及生化指标测量。所有参与者中，肥胖相关性高血压和高血压总体患病率（收缩压≥130mmHg 和/或舒张压≥80mmHg 或治疗性高血压）分别为 22.8%和 57.4%。对于肥胖相关性高血压，女性患病率高于男性（24.7%比 19.4%，p<0.001）。40-49、50-59、60-69 和≥70 岁年龄组中，肥胖相关性高血压的患病率分别为 11.8%、22.6%、30.7%和 36.6%。与非肥胖相关性高血压患者相比，肥胖相关性高血压患者更易发生高三酰甘油血症、高低密度脂蛋白胆固醇血症、糖尿病和高尿酸血症（均 p<0.05）。多因素 logistic 回归分析显示，年龄、女性、当前吸烟、高三酰甘油血症、糖尿病和高血压家族史均与肥胖相关性高血压呈正相关，而较高的教育程度和有配偶与肥胖相关性高血压呈负相关。中国西南地区 40 至 79 岁成年人中肥胖相关性高血压患病率较高。肥胖相关性高血压患者的心血管代谢异常较非肥胖相关性高血压患者更为严重且更为常见。需要采取积极全面的策略来预防和治疗肥胖相关性高血压。
