Division of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan, ROC.
Adv Drug Deliv Rev. 2018 Jan 1;123:155-164. doi: 10.1016/j.addr.2017.10.010. Epub 2017 Oct 24.
Significant skin pigmentation changes occur when patients suffer deep burn injuries. These pigmentation disorders may cause not only cosmetic and psychological issues, but more importantly it increases the risk of skin cancer or photoaging. Severe burns significantly effect on the process of repigmentation as the pigmentation is tightly regulated by cell proliferation and differentiation of melanocytes and melanocyte stem cells which are housing in the epidermis and hair follicles of the skin. In the present review, we discuss the possible mechanisms to replenish the melanocytes from the healthy epidermis and hair follicles surrounding burn wounds. The molecular mechanisms of skin repigmentation following healing of burn injuries includes the differentiation of melanoblasts into melanocytes, the distribution and responses of melanocytes and melanocyte stem cells after burn injury, and the regulation of melanin production. We also reviewed advanced therapeutic strategies to treat pigmentation disorders, such as convectional surgery, laser, UV treatment and emerging concepts in skin tissue-engineering.
当患者遭受深度烧伤时，会发生明显的皮肤色素沉着变化。这些色素沉着障碍不仅会导致美容和心理问题，更重要的是会增加皮肤癌或光老化的风险。严重烧伤会显著影响复色过程，因为色素沉着受到黑色素细胞和黑色素干细胞增殖和分化的严格调节，这些细胞位于皮肤的表皮和毛囊中。在本综述中，我们讨论了从健康的表皮和烧伤周围的毛囊中补充黑色素细胞的可能机制。烧伤愈合后皮肤复色的分子机制包括黑素母细胞分化为黑色素细胞、烧伤后黑色素细胞和黑色素干细胞的分布和反应，以及黑色素生成的调节。我们还回顾了治疗色素沉着障碍的先进治疗策略，如传统手术、激光、UV 处理以及皮肤组织工程中的新兴概念。
