Roddy Erika, DeBaun Malcolm R, Daoud-Gray Adam, Yang Yunzhi P, Gardner Michael J
School of Medicine, University of California, San Francisco (UCSF), 513 Parnassus Ave, San Francisco, CA, 94143, USA.
Department of Orthopaedic Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Eur J Orthop Surg Traumatol. 2018 Apr;28(3):351-362. doi: 10.1007/s00590-017-2063-0. Epub 2017 Oct 28.
Critical-sized bone defects are defined as those that will not heal spontaneously within a patient's lifetime. Current treatment options include vascularized bone grafts, distraction osteogenesis, and the induced membrane technique. The induced membrane technique is an increasingly utilized method with favorable results including high rates of union. Tissue engineering holds promise in the treatment of large bone defects due to advancement of stem cell biology, novel biomaterials, and 3D bioprinting. In this review, we provide an overview of the current operative treatment strategies of critical-sized bone defects as well as the current state of tissue engineering for such defects.
临界尺寸骨缺损被定义为那些在患者一生中不会自发愈合的骨缺损。目前的治疗选择包括带血管蒂骨移植、牵张成骨和诱导膜技术。诱导膜技术是一种越来越常用的方法，效果良好，包括高愈合率。由于干细胞生物学、新型生物材料和3D生物打印技术的进步，组织工程在治疗大的骨缺损方面具有广阔前景。在本综述中，我们概述了临界尺寸骨缺损目前的手术治疗策略以及针对此类缺损的组织工程现状。
