Walsh Tiffany R
Institute for Frontier Materials, Deakin University, Geelong, VIC, 3216, Australia.
Adv Exp Med Biol. 2017;1030:37-50. doi: 10.1007/978-3-319-66095-0_3.
The molecular-level interactions between peptides and medically-relevant biomaterials, including nanoparticles, have the potential to advance technologies aimed at improving performance for medical applications including tissue implants and regenerative medicine. Peptides can possess materials-selective non-covalent adsorption properties, which in this instance can be exploited to enhance the biocompatibility and possible multi-functionality of medical implant materials. However, at present, their successful implementation in medical applications is largely on a trial-and-error basis, in part because a deep comprehension of general structure/function relationships at these interfaces is currently lacking. Molecular simulation approaches can complement experimental characterisation techniques and provide a wealth of relevant details at the atomic scale. In this Chapter, progress and prospects for advancing peptide-mediated medical implant surface treatments via molecular simulation is summarised for two of the most widely-found medical implant interfaces, titania and hydroxyapatite.
肽与包括纳米颗粒在内的医学相关生物材料之间的分子水平相互作用，有可能推动旨在提高包括组织植入物和再生医学在内的医疗应用性能的技术发展。肽可以具有材料选择性非共价吸附特性，在这种情况下，可利用该特性来增强医疗植入材料的生物相容性和可能的多功能性。然而，目前它们在医疗应用中的成功实施很大程度上是基于反复试验，部分原因是目前缺乏对这些界面上一般结构/功能关系的深入理解。分子模拟方法可以补充实验表征技术，并在原子尺度上提供大量相关细节。在本章中，针对两种最常见的医疗植入界面——二氧化钛和羟基磷灰石，总结了通过分子模拟推进肽介导的医疗植入物表面处理的进展和前景。
