Tieland M, Franssen R, Dullemeijer C, van Dronkelaar C, Kyung Kim H, Ispoglou T, Zhu K, Prince R L, van Loon L J C, de Groot L C P G M
Prof. Lisette C.P.G.M. de Groot, PhD, Wageningen University, Division of Human Nutrition, PO Box 8129, 6700 EV Wageningen (the Netherlands), Telephone: +31 317 482577, E-mail:
J Nutr Health Aging. 2017;21(9):994-1001. doi: 10.1007/s12603-017-0896-1.
Increasing protein or amino acid intake has been promoted as a promising strategy to increase muscle mass and strength in elderly people, however, long-term intervention studies show inconsistent findings. Therefore, we aim to determine the impact of protein or amino acid supplementation compared to placebo on muscle mass and strength in older adults by combining the results from published trials in a meta-analysis and pooled individual participant data analysis.
We searched Medline and Cochrane databases and performed a meta-analysis on eight available trials on the effect of protein or amino acid supplementation on muscle mass and strength in older adults. Furthermore, we pooled individual data of six of these randomized double-blind placebo-controlled trials. The main outcomes were change in lean body mass and change in muscle strength for both the meta-analysis and the pooled analysis.
The meta-analysis of eight studies (n=557) showed no significant positive effects of protein or amino acid supplementation on lean body mass (mean difference: 0.014 kg: 95% CI -0.152; 0.18), leg press strength (mean difference: 2.26 kg: 95% CI -0.56; 5.08), leg extension strength (mean difference: 0.75 kg: 95% CI: -1.96, 3.47) or handgrip strength (mean difference: -0.002 kg: 95% CI -0.182; 0.179). Likewise, the pooled analysis showed no significant difference between protein and placebo treatment on lean body mass (n=412: p=0.78), leg press strength (n=121: p=0.50), leg extension strength (n=121: p=0.16) and handgrip strength (n=318: p=0.37).
There is currently no evidence to suggest that protein or amino acid supplementation without concomitant nutritional or exercise interventions increases muscle mass or strength in predominantly healthy elderly people.
增加蛋白质或氨基酸摄入量已被视为一种有望增加老年人肌肉量和力量的策略，然而，长期干预研究结果并不一致。因此，我们旨在通过对已发表试验结果进行荟萃分析并汇总个体参与者数据分析，来确定与安慰剂相比，补充蛋白质或氨基酸对老年人肌肉量和力量的影响。
我们检索了Medline和Cochrane数据库，并对八项关于蛋白质或氨基酸补充剂对老年人肌肉量和力量影响的现有试验进行荟萃分析。此外，我们汇总了其中六项随机双盲安慰剂对照试验的个体数据。荟萃分析和汇总分析的主要结局均为瘦体重变化和肌肉力量变化。
八项研究（n = 557）的荟萃分析显示，补充蛋白质或氨基酸对瘦体重（平均差异：0.014 kg：95%CI -0.152；0.18）、腿举力量（平均差异：2.26 kg：95%CI -0.56；5.08）、腿伸展力量（平均差异：0.75 kg：95%CI：-1.96，3.47）或握力（平均差异：-0.002 kg：95%CI -0.182；）均无显著积极影响。同样，汇总分析显示，蛋白质和安慰剂治疗在瘦体重（n = 412：p = 0.78）、腿举力量（n = 121：p = 0.50）、腿伸展力量（n = 121：p = 0.16）和握力（n = 318：p = 0.37）方面无显著差异。
目前没有证据表明，在没有同时进行营养或运动干预的情况下，补充蛋白质或氨基酸能增加主要健康的老年人的肌肉量或力量。 0.179）
0.179）
原文中“95%CI -0.182; 0.179”和“95%CI：-1.96, 3.47”括号内冒号使用不规范，翻译时保留了原文格式。
