Baby Sojan, Murthy Pratima, Thennarasu K, Chand Prabhat K, Viswanath Biju
Department of Psychiatry, Centre for Addiction Medicine, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.
Department of Biostatistics, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.
Indian J Psychiatry. 2017 Jul-Sep;59(3):293-299. doi: 10.4103/psychiatry.IndianJPsychiatry_260_17.
Delirium tremens (DT) is a medical emergency. Many cases are treated and discharged from emergency services (ES), after complete or partial resolution of delirium. Few receive comprehensive inpatient addiction treatment (CIAT) after the initial emergency management.
The objective of this study was to compare 6-month outcomes of treatment in alcohol-dependence syndrome (ADS) patients presenting with DT receiving either only emergency care or emergency care along with CIAT.
In this prospective observational study, all patients of ADS presenting in DT over a 1-year period were followed up for 6 months. Patients who received care only in the emergency services (ES) (111) were compared with patients who received ES followed by CIAT (90). Primary followup measure was regular followup (RFU) at outpatient department, and patients not presenting for RFU received telephonic followup (TFU). Alcohol use status was monitored at 6 months, as per Feuerlein and Küfner criteria.
Patients who received both ES and CIAT had better RFU compared to patients treated in the ES alone at 6 months (71/90 vs. 17/111, respectively, < 0.005). CIAT also resulted in better combined follow-up (RFU and TFU) (85/90 vs. 60/111, respectively, < 0.005). Compared to ES treatment group alone, ES plus CIAT group had fewer relapses (41/85 vs. 42/60, respectively, < 0.05). The most common reason for direct discharge from ES was nonavailability of beds for inpatient treatment.
Merely emergency treatment of ADS patients presenting with DT does not provide satisfactory treatment outcome with respect to alcohol use. ES treatment followed by CIAT ensures better outcome in the form of fewer relapses and better follow up.
震颤谵妄(DT)是一种医疗急症。许多病例在谵妄完全或部分缓解后,由急诊服务部门(ES)进行治疗并出院。在初始急诊处理后,很少有患者接受全面的住院成瘾治疗(CIAT)。
本研究的目的是比较酒精依赖综合征(ADS)合并DT的患者,接受单纯急诊治疗或急诊治疗加CIAT后的6个月治疗效果。
在这项前瞻性观察研究中,对1年内出现DT的所有ADS患者进行了6个月的随访。将仅在急诊服务部门(ES)接受治疗的患者(111例)与接受ES治疗后再接受CIAT的患者(90例)进行比较。主要随访指标是门诊定期随访(RFU),未前来进行RFU的患者接受电话随访(TFU)。根据Feuerlein和Küfner标准,在6个月时监测酒精使用情况。
在6个月时,接受ES和CIAT治疗的患者的RFU情况优于仅接受ES治疗的患者(分别为71/90和17/111,<0.005)。CIAT还带来了更好的综合随访效果(RFU和TFU)(分别为85/90和60/111,<0.005)。与仅ES治疗组相比,ES加CIAT组的复发率更低(分别为41/85和42/60,<0.05)。ES直接出院的最常见原因是没有住院治疗床位。
对于出现DT的ADS患者,仅进行急诊治疗在酒精使用方面不能提供令人满意的治疗效果。ES治疗后再进行CIAT可确保更好的治疗效果,表现为复发率更低和随访情况更好。