Teixeira Francisco B, Saito Miki T, Matheus Filipe C, Prediger Rui D, Yamada Elizabeth S, Maia Cristiane S F, Lima Rafael R
Institute of Biological Science, Federal University of Pará, Belém, Brazil.
College of Medicine, Federal University of Pará, Altamira, Brazil.
Front Aging Neurosci. 2017 Oct 10;9:327. doi: 10.3389/fnagi.2017.00327. eCollection 2017.
Periodontitis is an oral chronic infection/inflammatory condition, identified as a source of mediators of inflammation into the blood circulation, which may contribute to exacerbate several diseases. There is increasing evidence that inflammation plays a key role in the pathophysiology of Alzheimer's disease (AD). Although inflammation is present in both diseases, the exact mechanisms and crosslinks between periodontitis and AD are poorly understood. Therefore, this article aims to review possible comorbidity between periodontitis and AD. Here, the authors discuss the inflammatory aspects of periodontitis, how this oral condition produces a systemic inflammation and, finally, the contribution of this systemic inflammation for worsening neuroinflammation in the progression of AD.
牙周炎是一种口腔慢性感染/炎症性疾病，被认为是炎症介质进入血液循环的一个来源，这可能会促使多种疾病恶化。越来越多的证据表明，炎症在阿尔茨海默病（AD）的病理生理学中起着关键作用。虽然两种疾病中都存在炎症，但牙周炎与AD之间的确切机制和相互联系仍知之甚少。因此，本文旨在综述牙周炎与AD之间可能存在的共病关系。在此，作者讨论了牙周炎的炎症方面，这种口腔疾病如何引发全身炎症，以及这种全身炎症在AD进展过程中对神经炎症恶化的作用。
