• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
A circular twist on microRNA regulation.miRNA 调控的环状扭转。
Cell Res. 2017 Dec;27(12):1401-1402. doi: 10.1038/cr.2017.136. Epub 2017 Oct 31.
2
Crosstalk in competing endogenous RNA networks reveals new circular RNAs involved in the pathogenesis of early HIV infection.竞争内源性 RNA 网络中的串扰揭示了新的环状 RNA,它们参与了早期 HIV 感染的发病机制。
J Transl Med. 2018 Nov 29;16(1):332. doi: 10.1186/s12967-018-1706-1.
3
Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection.家蚕中肠感染质型多角体病毒后环状 RNA 的鉴定与特征分析。
RNA Biol. 2018 Feb 1;15(2):292-301. doi: 10.1080/15476286.2017.1411461. Epub 2017 Dec 21.
4
Microarray Analysis of Differentially Expressed Profiles of Circular RNAs in a Mouse Model of Intestinal Ischemia/Reperfusion Injury with and Without Ischemic Postconditioning.有无缺血后处理的肠缺血/再灌注损伤小鼠模型中环状RNA差异表达谱的基因芯片分析
Cell Physiol Biochem. 2018;48(4):1579-1594. doi: 10.1159/000492280. Epub 2018 Aug 2.
5
Microarray analysis of circular RNA expression patterns in polarized macrophages.极化巨噬细胞中环状RNA表达模式的微阵列分析
Int J Mol Med. 2017 Feb;39(2):373-379. doi: 10.3892/ijmm.2017.2852. Epub 2017 Jan 11.
6
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.骨肉瘤中环状RNA的基因芯片表达谱及功能分析
Cell Physiol Biochem. 2017;43(3):969-985. doi: 10.1159/000481650. Epub 2017 Sep 29.
7
Circular RNA expression and regulatory network prediction in posterior cingulate astrocytes in elderly subjects.老年人后扣带回星形胶质细胞中的环状 RNA 表达和调控网络预测。
BMC Genomics. 2018 May 9;19(1):340. doi: 10.1186/s12864-018-4670-5.
8
Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia.短暂性局灶性脑缺血后小鼠大脑中环状RNA表达谱发生显著改变。
Stroke. 2017 Sep;48(9):2541-2548. doi: 10.1161/STROKEAHA.117.017469. Epub 2017 Jul 12.
9
Identification and characterization of circular RNAs in zebrafish.斑马鱼中环状RNA的鉴定与特征分析
FEBS Lett. 2017 Jan;591(1):213-220. doi: 10.1002/1873-3468.12500. Epub 2016 Dec 19.
10
Identification of circRNAs for miRNA Targets by Argonaute2 RNA Immunoprecipitation and Luciferase Screening Assays.通过AGO2 RNA免疫沉淀和荧光素酶筛选试验鉴定miRNA靶标的环状RNA
Methods Mol Biol. 2018;1724:209-218. doi: 10.1007/978-1-4939-7562-4_17.

引用本文的文献

1
circARHGAP10 as a candidate biomarker and therapeutic target in myotonic dystrophy type 1.环状 ARHGAP10 作为 1 型强直性肌营养不良的候选生物标志物和治疗靶点。
Mol Ther Nucleic Acids. 2025 Jul 30;36(3):102646. doi: 10.1016/j.omtn.2025.102646. eCollection 2025 Sep 9.
2
Aurora-A promotes lenvatinib resistance experimentally through hsa-circ-0058046/miR-424-5p/FGFR1 axis in hepatocellular carcinoma.在实验中,极光激酶A通过人源环状RNA-0058046/微小RNA-424-5p/成纤维细胞生长因子受体1轴促进肝癌对乐伐替尼的耐药性。
Int J Immunopathol Pharmacol. 2025 Jan-Dec;39:3946320251316692. doi: 10.1177/03946320251316692.
3
A fishnet between nasopharyngeal carcinoma and resistance: the competing endogenous RNA network.鼻咽癌与抗性之间的“鱼网”:竞争性内源性RNA网络
Curr Treat Options Oncol. 2025 Jan;26(1):45-54. doi: 10.1007/s11864-024-01284-3. Epub 2025 Jan 15.
4
Circular RNA CircZNF644 Facilitates Circulating Follicular Helper T Cells Response in Patients with Graves' Disease.环状 RNA CircZNF644 促进 Graves 病患者循环滤泡辅助性 T 细胞反应。
J Immunol Res. 2024 Jun 27;2024:9527268. doi: 10.1155/2024/9527268. eCollection 2024.
5
Exosomal circSIPA1L3-mediated intercellular communication contributes to glucose metabolic reprogramming and progression of triple negative breast cancer.外泌体 circSIPA1L3 介导的细胞间通讯促进三阴性乳腺癌的葡萄糖代谢重编程和进展。
Mol Cancer. 2024 Jun 8;23(1):125. doi: 10.1186/s12943-024-02037-4.
6
CircAGFG1 Promotes Ovarian Cancer Progression Through the miR-409-3 p/ZEB1 Axis.环状 RNA AFGG1 通过 miR-409-3p/ZEB1 轴促进卵巢癌进展。
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241252423. doi: 10.1177/15330338241252423.
7
Circular RNAs: Diagnostic and Therapeutic Perspectives in CNS Diseases.环状RNA:中枢神经系统疾病的诊断与治疗前景
Curr Med Sci. 2023 Oct;43(5):879-889. doi: 10.1007/s11596-023-2784-8. Epub 2023 Oct 10.
8
CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway.环状 RNA UCP2 通过 miR-149/UCP2 通路促进非小细胞肺癌的肿瘤进展。
Oncol Res. 2023 Sep 15;31(6):929-936. doi: 10.32604/or.2023.030611. eCollection 2023.
9
CPSF3 Promotes Pre-mRNA Splicing and Prevents CircRNA Cyclization in Hepatocellular Carcinoma.CPSF3促进肝癌中的前体mRNA剪接并防止环状RNA环化
Cancers (Basel). 2023 Aug 11;15(16):4057. doi: 10.3390/cancers15164057.
10
Role(s) of G3BPs in Human Pathogenesis.G3BPs 在人类发病机制中的作用。
J Pharmacol Exp Ther. 2023 Oct;387(1):100-110. doi: 10.1124/jpet.122.001538. Epub 2023 Jul 19.

本文引用的文献

1
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.哺乳动物环状 RNA 基因座丢失导致 miRNA 失调并影响大脑功能。
Science. 2017 Sep 22;357(6357). doi: 10.1126/science.aam8526. Epub 2017 Aug 10.
2
Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7.沉默CDR1as通过调控微小RNA-7抑制结直肠癌进展。
Onco Targets Ther. 2017 Apr 7;10:2045-2056. doi: 10.2147/OTT.S131597. eCollection 2017.
3
The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression.环状RNA Cdr1as通过靶向miR-7表达在肝细胞癌中发挥癌基因作用。
PLoS One. 2016 Jul 8;11(7):e0158347. doi: 10.1371/journal.pone.0158347. eCollection 2016.
4
Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations.致癌融合环状 RNA 来源于与癌症相关的染色体易位。
Cell. 2016 Apr 7;165(2):289-302. doi: 10.1016/j.cell.2016.03.020. Epub 2016 Mar 31.
5
Considerations when investigating lncRNA function in vivo.在体内研究长链非编码RNA功能时的注意事项。
Elife. 2014 Aug 14;3:e03058. doi: 10.7554/eLife.03058.
6
Circular RNAs are a large class of animal RNAs with regulatory potency.环状 RNA 是一大类具有调控能力的动物 RNA。
Nature. 2013 Mar 21;495(7441):333-8. doi: 10.1038/nature11928. Epub 2013 Feb 27.
7
Natural RNA circles function as efficient microRNA sponges.天然 RNA 环作为有效的 microRNA 海绵发挥作用。
Nature. 2013 Mar 21;495(7441):384-8. doi: 10.1038/nature11993. Epub 2013 Feb 27.
8
Circular RNAs are abundant, conserved, and associated with ALU repeats.环状 RNA 丰富、保守,并与 ALU 重复序列相关。
RNA. 2013 Feb;19(2):141-57. doi: 10.1261/rna.035667.112. Epub 2012 Dec 18.
9
Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types.环状 RNA 是来自不同细胞类型数百个人类基因的主要转录本异构体。
PLoS One. 2012;7(2):e30733. doi: 10.1371/journal.pone.0030733. Epub 2012 Feb 1.
10
A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?一种 ceRNA 假说:隐藏 RNA 语言的罗塞塔石碑?
Cell. 2011 Aug 5;146(3):353-8. doi: 10.1016/j.cell.2011.07.014. Epub 2011 Jul 28.

miRNA 调控的环状扭转。

A circular twist on microRNA regulation.

机构信息

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

出版信息

Cell Res. 2017 Dec;27(12):1401-1402. doi: 10.1038/cr.2017.136. Epub 2017 Oct 31.

DOI:10.1038/cr.2017.136
PMID:29086764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5717405/
Abstract

Circular RNAs (circRNAs) are a novel class of RNA whose physiological function has yet to be investigated. A recent publication in Science provides the first evidence of the biological relevance of a circRNA in an in vivo model and unveils an unexpected twist on their crosstalk with miRNAs.

摘要

环状 RNA(circRNAs)是一类新型 RNA,其生理功能尚未得到研究。最近在《科学》杂志上发表的一项研究首次提供了 circRNA 在体内模型中具有生物学相关性的证据,并揭示了它们与 miRNA 相互作用的意外变化。