miRNA 调控的环状扭转。
A circular twist on microRNA regulation.
机构信息
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Cell Res. 2017 Dec;27(12):1401-1402. doi: 10.1038/cr.2017.136. Epub 2017 Oct 31.
Abstract
Circular RNAs (circRNAs) are a novel class of RNA whose physiological function has yet to be investigated. A recent publication in Science provides the first evidence of the biological relevance of a circRNA in an in vivo model and unveils an unexpected twist on their crosstalk with miRNAs.
摘要
环状 RNA（circRNAs）是一类新型 RNA，其生理功能尚未得到研究。最近在《科学》杂志上发表的一项研究首次提供了 circRNA 在体内模型中具有生物学相关性的证据，并揭示了它们与 miRNA 相互作用的意外变化。
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本文引用的文献
1
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Science. 2017 Sep 22;357(6357). doi: 10.1126/science.aam8526. Epub 2017 Aug 10.
2
Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7.沉默CDR1as通过调控微小RNA-7抑制结直肠癌进展。
Onco Targets Ther. 2017 Apr 7;10:2045-2056. doi: 10.2147/OTT.S131597. eCollection 2017.
3
The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression.环状RNA Cdr1as通过靶向miR-7表达在肝细胞癌中发挥癌基因作用。
PLoS One. 2016 Jul 8;11(7):e0158347. doi: 10.1371/journal.pone.0158347. eCollection 2016.
4
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Cell. 2016 Apr 7;165(2):289-302. doi: 10.1016/j.cell.2016.03.020. Epub 2016 Mar 31.
5
Considerations when investigating lncRNA function in vivo.在体内研究长链非编码RNA功能时的注意事项。
Elife. 2014 Aug 14;3:e03058. doi: 10.7554/eLife.03058.
6
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Nature. 2013 Mar 21;495(7441):333-8. doi: 10.1038/nature11928. Epub 2013 Feb 27.
7
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Nature. 2013 Mar 21;495(7441):384-8. doi: 10.1038/nature11993. Epub 2013 Feb 27.
8
Circular RNAs are abundant, conserved, and associated with ALU repeats.环状 RNA 丰富、保守，并与 ALU 重复序列相关。
RNA. 2013 Feb;19(2):141-57. doi: 10.1261/rna.035667.112. Epub 2012 Dec 18.
9
Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types.环状 RNA 是来自不同细胞类型数百个人类基因的主要转录本异构体。
PLoS One. 2012;7(2):e30733. doi: 10.1371/journal.pone.0030733. Epub 2012 Feb 1.
10
A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?一种 ceRNA 假说：隐藏 RNA 语言的罗塞塔石碑？
Cell. 2011 Aug 5;146(3):353-8. doi: 10.1016/j.cell.2011.07.014. Epub 2011 Jul 28.
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