Department of Pediatrics, Columbia University, 630 W. 168th St, New York, NY 10032, USA; Mailman School Public Health, Columbia University, 722 W. 168th St, New York, NY 10032, USA; NewYork Presbyterian Hospital, New York, NY 3959 Broadway, New York, NY 10032, USA.
Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, 670 Albany St, Boston, MA 02118, USA.
Vaccine. 2017 Dec 15;35(50):6941-6948. doi: 10.1016/j.vaccine.2017.10.073. Epub 2017 Oct 28.
Using text messaging for vaccine safety monitoring, particularly for non-medically attended events, would be valuable for pandemic influenza and emergency vaccination program preparedness. We assessed the feasibility and acceptability of text messaging to evaluate fever and wheezing post-influenza vaccination in a prospective, observational, multi-site pediatric study.
Children aged 2-11 years old, with an emphasis on children with asthma, were recruited during the 2014-2015 influenza season from three community-based clinics in New York City, and during the 2014-2015 and 2015-2016 seasons from a private practice in Fall River, Massachusetts. Parents of enrolled children receiving quadrivalent live attenuated (LAIV4) or inactivated influenza vaccine (IIV4) replied to text messages assessing respiratory symptoms (day 3 and 7, then weekly through day 42), and temperature on the night of vaccination and the next seven nights (day 0-7). Missing data were collected via diary (day 0-7 only) and phone. Phone confirmation was obtained for both presence and absence of respiratory symptoms. Reporting rates, fever (T≥100.4 °F) frequency, proportion of wheezing and/or chest tightness reports captured via text message versus all sources (text, phone, diary, electronic health record) and parental satisfaction were assessed.
Across both seasons, 266 children were analyzed; 49.2% with asthma. Parental text message response rates were high (>70%) across sites. Overall, fever frequency was low (day 0-2: 4.1% [95% confidence interval (CI) 2.3-7.4%]; d3-7: 6.7% [95% CI 4.1-10.8%]). A third (39.2%) of parents reported a respiratory problem in their child, primarily cough. Most (88.2%) of the 52 wheezing and/or chest tightness reports were by text message. Most (88.1%) participants preferred text messaging over paper reporting.
Text messaging can provide information about pediatric post-vaccination fever and wheezing and was viewed positively by parents. It could be a helpful tool for rapid vaccine safety monitoring during a pandemic or other emergency vaccination program.
clinicaltrials.gov Identifier: NCT02295007.
利用短信进行疫苗安全性监测，尤其是针对非医疗性事件，对于大流行性流感和应急疫苗接种计划的准备非常有价值。我们评估了前瞻性、多地点儿科研究中使用短信评估流感疫苗接种后发热和喘息的可行性和可接受性。
在纽约市的三个社区诊所和马萨诸塞州的法尔河的一家私人诊所，2014-2015 流感季节招募了 2-11 岁的儿童，重点是患有哮喘的儿童。入组儿童的父母在接种四价减毒活（LAIV4）或灭活流感疫苗（IIV4）后回复短信，评估呼吸道症状（第 3 天和第 7 天，然后每周至第 42 天），以及接种当晚和接下来的 7 晚的体温（第 0-7 天）。通过日记（仅第 0-7 天）和电话收集缺失数据。对于存在和不存在呼吸道症状，都通过电话进行了确认。评估了报告率、发热（T≥100.4°F）频率、通过短信与所有来源（短信、电话、日记、电子健康记录）报告的喘息和/或胸闷比例以及父母满意度。
两个季节共分析了 266 名儿童；49.2%有哮喘。各地父母短信回复率均较高（>70%）。总体而言，发热频率较低（第 0-2 天：4.1%[95%置信区间（CI）2.3-7.4%]；第 3-7 天：6.7%[95% CI 4.1-10.8%]）。三分之一（39.2%）的父母报告其孩子出现呼吸道问题，主要是咳嗽。88.2%（52 次）的喘息和/或胸闷报告主要通过短信报告。88.1%的参与者更喜欢短信报告而非纸质报告。
短信可以提供儿童接种疫苗后发热和喘息的信息，并且受到父母的积极评价。在大流行或其他应急疫苗接种计划期间，它可能是快速疫苗安全性监测的有用工具。
clinicaltrials.gov 标识符：NCT02295007。
