Griffin Isabel, Zhang Guoyan, Fernandez Danielle, Cordero Christina, Logue Teresa, White Stephen L, Llau Anthoni, Thomas Lakisha, Moore Emily, Noya-Chaveco Pedro, Etienne Marie, Rojas Mercedes, Goldberg Cynthia, Rodriguez Genevie, Mejia-Echeverry Alvaro, Rico Edhelene, Gillis Leah D, Cone Marshall, Jean Reynald, Rivera Lillian
Department of Epidemiology, Disease Control, and Immunization Services, Florida Department of Health in Miami-Dade County, Miami, Florida; and
Department of Epidemiology, Disease Control, and Immunization Services, Florida Department of Health in Miami-Dade County, Miami, Florida; and.
Pediatrics. 2017 Dec;140(6). doi: 10.1542/peds.2017-2044. Epub 2017 Nov 1.
In July 2016, local transmission of Zika virus (ZIKV) was announced in Miami-Dade County, Florida. In this report, we describe the epidemiology of pediatric ZIKV infections in locally acquired and travel-associated cases.
All children aged 1 to 17 years tested for ZIKV between October 1, 2015, and March 29, 2017, were included. SAS 9.4 was used to analyze age, sex, race and/or ethnicity, origin of exposure, onset date, affiliation with a household cluster, clinical symptoms, hospitalizations, viremia, viruria, and antibody detection in specimens.
Among 478 confirmed ZIKV cases in Miami-Dade County, 33 (6.9%) occurred in children (1-17 years). Twenty-seven (82.3%) cases were travel-associated. The median age of a pediatric Zika case patient was 11 years. Seventeen (51.5%) case patients were boys, and 23 (69.9%) were Hispanic. Among 31 symptomatic cases, all reported having rash, 25 (80.6%) reported fever, 9 (29.0%) reported conjunctivitis, and 7 (22.6%) reported arthralgia. Sixteen (48.5%) cases reported 2 of 4 and 8 (24.2%) reported 3 of 4 main symptoms.
This report found that the majority of children identified during the 2016 ZIKV outbreak only presented with 2 of the 4 main symptoms. In addition, pediatric ZIKV cases were frequently associated with symptomatic household members.
2016年7月，佛罗里达州迈阿密-戴德县宣布出现寨卡病毒（ZIKV）本地传播。在本报告中，我们描述了本地感染和旅行相关病例中儿童寨卡病毒感染的流行病学情况。
纳入2015年10月1日至2017年3月29日期间接受寨卡病毒检测的所有1至17岁儿童。使用SAS 9.4分析年龄、性别、种族和/或族裔、暴露源、发病日期、与家庭聚集性病例的关联、临床症状、住院情况、病毒血症、病毒尿症以及标本中的抗体检测情况。
在迈阿密-戴德县478例确诊的寨卡病毒病例中，33例（6.9%）发生在儿童（1至17岁）。27例（82.3%）病例与旅行相关。儿童寨卡病例患者的中位年龄为11岁。17例（51.5%）病例患者为男孩，23例（69.9%）为西班牙裔。在31例有症状的病例中，所有患者均报告有皮疹，25例（80.6%）报告有发热，9例（29.0%）报告有结膜炎，7例（22.6%）报告有关节痛。16例（48.5%）病例报告有4种主要症状中的2种，8例（24.2%）报告有4种主要症状中的3种。
本报告发现，在2016年寨卡病毒疫情期间确诊的大多数儿童仅出现4种主要症状中的2种。此外，儿童寨卡病毒病例常与有症状的家庭成员有关。
