Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Bioinformatics Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, P.O. Box 79, Sadat City, Egypt.
Biomed Res Int. 2017;2017:3098745. doi: 10.1155/2017/3098745. Epub 2017 Sep 28.
Hypercholesterolemia is commonly associated with obesity that leads to heart diseases and diabetes. The hepatocardioprotective activity of parsley and carob methanol extract was tested in hypercholesterolemic male rats. Twenty-four male albino rats were divided into four groups ( = 6). Group 1 was the negative control group fed with fat rich diet, group 2 (G2) was hypercholesterolemic rats fed with fat rich diet with 2% cholesterol, and group 3 and group 4 (G3 and G4) were hypercholesterolemic rats supplemented with 2% cholesterol and cotreated with 20% w/w parsley seed methanol extract and 20% w/w carob legume methanol extract, respectively. The experiment was conducted for eight weeks. The positive hypercholesterolemic rats showed significant increase in serum levels of total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), lactate dehydrogenase (LDH), creatine kinase-mb, liver function enzymes, and decrease in the high density lipoproteins (HDL). Moreover, heart and liver tissues were ameliorated and nearly restored their normal appearance. It could be concluded that both parsley and carob extracts supplementations have a protective effect against hyperlipidemia and improved the histological alteration in heart and liver tissues. The methanol extract of parsley appeared to be more efficient than that of carob in lowering hypercholesterolemia.
高胆固醇血症通常与肥胖有关，而肥胖会导致心脏病和糖尿病。本研究旨在测试欧芹和角豆甲醇提取物对高胆固醇血症大鼠的肝心保护作用。将 24 只雄性白化大鼠分为 4 组（每组 6 只）。第 1 组为阴性对照组，给予高脂饮食；第 2 组（G2）为高胆固醇血症大鼠，给予高脂饮食并添加 2%胆固醇；第 3 组和第 4 组（G3 和 G4）为高胆固醇血症大鼠，给予高脂饮食并分别添加 2%胆固醇和 20%（w/w）欧芹籽甲醇提取物及 20%（w/w）角豆豆荚甲醇提取物。实验进行了 8 周。阳性高胆固醇血症大鼠的血清总胆固醇、甘油三酯、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）、乳酸脱氢酶（LDH）、肌酸激酶同工酶-MB、肝功能酶水平显著升高，高密度脂蛋白（HDL）水平降低。此外，心脏和肝脏组织得到改善，几乎恢复正常外观。这表明，欧芹和角豆提取物补充剂均具有抗高血脂作用，并改善了心脏和肝脏组织的组织学变化。与角豆相比，欧芹甲醇提取物在降低高胆固醇血症方面似乎更有效。
