a Department of Corneal and External Eye Diseases, St. Paul's Eye Unit , The Royal Liverpool University Hospital , Liverpool , UK.
b Department of Ophthalmology , Medical University of Innsbruck , Innsbruck , Austria.
Ocul Immunol Inflamm. 2019;27(2):276-281. doi: 10.1080/09273948.2017.1387276. Epub 2017 Nov 2.
To investigate a pixel densitometry index (PDI) for measuring ocular surface inflammation (OSI).
Efron's grading was performed by two independent observers. Color photographs and indocyanine green angiography were undertaken before and after instillation of phenylephrine (PE) hydrochloride 2.5%.
A total of 15 patients with and 10 without OSI were included. PDI before and after PE was 73.29 ± 30.71 and 50.87 ± 17.46 (p = 0.036) in patients with inflammation and 52.86 ± 16.90 and 39.63 ± 12.04 (p = 0.0024) in those without OSI. The reduction in Efron grades following PE was 25% (mean 0.46 ± 0.50, median 0.50; p < 0.01). The coefficient of variation pre- and post-PE was lower using the PDI (42% and 50%) than with the Efron grades (59% and 72%).
The PDI allows the objective detection of change in conjunctival hyperemia with potential direct applicability to noninvasive angiography such as optical coherence tomography-based angiography.
研究一种用于测量眼表炎症（OSI）的像素密度计量指数（PDI）。
由两名独立观察者进行 Efron 分级。在滴入盐酸苯肾上腺素（PE）2.5%前后进行彩色照相和吲哚菁绿血管造影。
共纳入 15 例有 OSI 和 10 例无 OSI 的患者。炎症患者 PE 前后的 PDI 分别为 73.29 ± 30.71 和 50.87 ± 17.46（p = 0.036），无 OSI 患者的 PDI 分别为 52.86 ± 16.90 和 39.63 ± 12.04（p = 0.0024）。PE 后 Efron 分级的降低幅度为 25%（平均 0.46 ± 0.50，中位数 0.50；p < 0.01）。PE 前后的 PDI 变异系数（42%和 50%）低于 Efron 分级（59%和 72%）。
PDI 可客观检测结膜充血的变化，可能直接适用于非侵入性血管造影，如基于光学相干断层扫描的血管造影。
