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眼部发红 - I:结膜充血的病因、发病机制及评估

Ocular redness - I: Etiology, pathogenesis, and assessment of conjunctival hyperemia.

作者信息

Singh Rohan Bir, Liu Lingjia, Anchouche Sonia, Yung Ann, Mittal Sharad K, Blanco Tomas, Dohlman Thomas H, Yin Jia, Dana Reza

机构信息

Laboratory of Corneal Immunology, Transplantation and Regeneration, Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

Laboratory of Corneal Immunology, Transplantation and Regeneration, Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

出版信息

Ocul Surf. 2021 Jul;21:134-144. doi: 10.1016/j.jtos.2021.05.003. Epub 2021 May 16.

DOI:10.1016/j.jtos.2021.05.003
PMID:34010701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8328962/
Abstract

The translucent appearance of the conjunctiva allows for immediate visualization of changes in the circulation of the conjunctival microvasculature consisting of extensive branching of superficial and deep arterial systems and corresponding drainage pathways, and the translucent appearance of the conjunctiva allows for immediate visualization of changes in the circulation. Conjunctival hyperemia is caused by a pathological vasodilatory response of the microvasculature in response to inflammation due to a myriad of infectious and non-infectious etiologies. It is one of the most common contributors of ocular complaints that prompts visits to medical centers. Our understanding of these neurogenic and immune-mediated pathways has progressed over time and has played a critical role in developing targeted novel therapies. Due to a multitude of underlying etiologies, patients must be accurately diagnosed for efficacious management of conjunctival hyperemia. The diagnostic techniques used for the grading of conjunctival hyperemia have also evolved from descriptive and subjective grading scales to more reliable computer-based objective grading scales.

摘要

结膜的半透明外观使得能够立即观察到结膜微血管循环的变化,结膜微血管循环由浅表和深部动脉系统的广泛分支以及相应的引流途径组成,并且结膜的半透明外观使得能够立即观察到循环的变化。结膜充血是由微血管对多种感染性和非感染性病因引起的炎症作出的病理性血管舒张反应所致。它是促使患者前往医疗中心就诊的最常见眼部症状之一。随着时间的推移,我们对这些神经源性和免疫介导途径的理解取得了进展,并且在开发有针对性的新型疗法中发挥了关键作用。由于存在多种潜在病因,必须对患者进行准确诊断,以便有效管理结膜充血。用于结膜充血分级的诊断技术也已从描述性和主观分级量表发展为更可靠的基于计算机的客观分级量表。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d39/8328962/0c1877475945/nihms-1711488-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d39/8328962/7dbd37f7ab60/nihms-1711488-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d39/8328962/6b20f8ffb98f/nihms-1711488-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d39/8328962/f94dbfc65cfb/nihms-1711488-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d39/8328962/c077b3547f07/nihms-1711488-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d39/8328962/0c1877475945/nihms-1711488-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d39/8328962/7dbd37f7ab60/nihms-1711488-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d39/8328962/6b20f8ffb98f/nihms-1711488-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d39/8328962/f94dbfc65cfb/nihms-1711488-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d39/8328962/c077b3547f07/nihms-1711488-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d39/8328962/0c1877475945/nihms-1711488-f0004.jpg

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