Idowu O A, Heading K L
Melbourne Veterinary Specialist Centre, 70 Blackburn Road, Glen Waverley, Melbourne, 3150 Australia.
J Small Anim Pract. 2018 Mar;59(3):183-187. doi: 10.1111/jsap.12774. Epub 2017 Nov 2.
To investigate whether there is a temporal relationship between vaccination and the onset of type 1 immune-mediated polyarthritis in dogs.
Retrospective case-control study: 39 dogs from a referral hospital with a diagnosis of type 1 immune-mediated polyarthritis were age-matched with 78 control dogs with other diagnoses. A temporal association between vaccination and polyarthritis was considered positive if recent vaccination had been performed within 28 days of the onset of clinical signs of immune-mediated polyarthritis. The odds ratio association of recent vaccination with immune-mediated polyarthritis was calculated using matched case-control methods.
Of the 39 dogs in the type 1 immune-mediated polyarthritis group, four had been vaccinated within 28 days before onset of clinical signs compared to six dogs in the control group. The odds ratio for a dog developing type 1 immune-mediated polyarthritis if vaccinated within the last 28 days was estimated to be 1·44 (95% confidence interval 0·25 to 8·24, P = 0·88).
There was no evidence of a temporal relationship between vaccination and type 1 immune-mediated polyarthritis, although the large confidence interval on the odds ratio suggests a need for larger studies to confirm this finding.
研究犬类接种疫苗与1型免疫介导性多关节炎发病之间是否存在时间关系。
回顾性病例对照研究：从一家转诊医院选取39只被诊断为1型免疫介导性多关节炎的犬，与78只患有其他疾病的对照犬进行年龄匹配。如果在免疫介导性多关节炎临床症状出现的28天内进行了近期疫苗接种，则疫苗接种与多关节炎之间的时间关联被视为阳性。使用匹配病例对照方法计算近期疫苗接种与免疫介导性多关节炎的优势比关联。
在1型免疫介导性多关节炎组的39只犬中，有4只在临床症状出现前28天内接种了疫苗，而对照组中有6只犬。估计在过去28天内接种疫苗的犬发生1型免疫介导性多关节炎的优势比为1.44（95%置信区间0.25至8.24，P = 0.88）。
没有证据表明疫苗接种与1型免疫介导性多关节炎之间存在时间关系，尽管优势比的置信区间较大，表明需要进行更大规模的研究来证实这一发现。
