PET/MR 上肝脏 18F-FDG 摄取测量：感兴趣区位置对可重复性的影响。
Hepatic 18F-FDG Uptake Measurements on PET/MR: Impact of Volume of Interest Location on Repeatability.
机构信息
Department of Nuclear Medicine, Assuta Medical Centers, Tel Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
出版信息
Contrast Media Mol Imaging. 2017 May 30;2017:8639731. doi: 10.1155/2017/8639731. eCollection 2017.
BACKGROUND
To investigate same day 18F-FDG (Fluorodeoxyglucose) PET (Positron Emission Tomography)/MR (Magnetic Resonance) test-retest repeatability of Standardized Uptake Value measurements normalized for body weight (SUV) and lean body mass (SUL) in different locations in the liver.
METHODS
This prospective study was IRB approved with written informed consent obtained. 35 patients (20 women and 15 men, 61 ± 11.2 years) that performed a whole-body 18F-FDG PET/MR followed by liver-dedicated contrast-enhanced 18F-FDG PET/MR were included. SUV/L max, mean, and peak were measured inferior to, superior to, and at the right portal vein and in the left lobe of the liver. The coefficient of variation (CV) and intraclass correlation coefficient (ICC) were calculated and Bland-Altman plots were obtained.
RESULTS
The variability for SUV/L's measurements was lowest inferior to the portal vein (<9.2%) followed by measurements performed at the level of the portal vein (<14.6%).
CONCLUSION
The area inferior to the portal vein is the most reliable location for hepatic 18F-FDG uptake measurements on PET/MR.
背景
研究同一天进行的 18F-FDG（氟脱氧葡萄糖）PET（正电子发射断层扫描）/MR（磁共振）检测中，肝内不同部位标准化摄取值（SUV）和去脂体重标准化摄取值（SUL）的重复性。
方法
这项前瞻性研究获得了机构审查委员会的批准和书面知情同意。共纳入 35 名患者（20 名女性和 15 名男性，61±11.2 岁），他们接受了全身 18F-FDG PET/MR 检查，随后进行了肝脏专用对比增强 18F-FDG PET/MR 检查。在门静脉下方、上方和门静脉水平以及肝左叶测量 SUV/Lmax、平均值和峰值。计算变异系数（CV）和组内相关系数（ICC），并获得 Bland-Altman 图。
结果
SUV/L 测量的变异性最低，位于门静脉下方（<9.2%），其次是门静脉水平（<14.6%）。
结论
在 PET/MR 上，肝 18F-FDG 摄取测量的最可靠位置是门静脉下方区域。
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