Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, People's Republic of China.
Lab Chip. 2017 Dec 19;18(1):41-56. doi: 10.1039/c7lc00800g.
In recent years, a broad range of nanocrystals have been synthesized in droplet-based microfluidic reactors which provide obvious advantages, such as accurate manipulation, better reproducibility and reliable automation. In this review, we initially introduce general concepts of droplet reactors followed by discussions of their main functional regions including droplet generation, mixing of reactants, reaction controlling, in situ monitoring, and reaction quenching. Subsequently, the enhanced mass and heat transport properties are discussed. Next, we focus on research frontiers including sequential multistep synthesis, intelligent synthesis, reliable scale-up synthesis, and interfacial synthesis. Finally, we end with an outlook on droplet reactors, especially highlighting some aspects such as large-scale production, the integrated process of synthesis and post-synthetic treatments, automated droplet reactors with in situ monitoring and optimizing algorithms, and rapidly developing strategies for interfacial synthesis.
近年来，在基于液滴的微流控反应器中合成了广泛的纳米晶体，这些反应器具有明显的优势，如精确的操作、更好的重现性和可靠的自动化。在这篇综述中，我们首先介绍了液滴反应器的一般概念，然后讨论了其主要功能区域，包括液滴的生成、反应物的混合、反应控制、原位监测和反应淬灭。随后，讨论了增强的质量和传热性质。接下来，我们关注的研究前沿包括顺序多步合成、智能合成、可靠的规模化合成和界面合成。最后，我们对液滴反应器进行了展望，特别是强调了一些方面，如大规模生产、合成和后处理的集成工艺、具有原位监测和优化算法的自动化液滴反应器，以及界面合成的快速发展策略。
