Lin Wei-Yu, Wang Yanju, Wang Shutao, Tseng Hsian-Rong
Department of Molecular and Medical Pharmacology, Crump institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), California NanoSystems Institute (CNSI), University of California, Los Angeles, Los Angeles, CA, USA.
Nano Today. 2009 Dec;4(6):470-481. doi: 10.1016/j.nantod.2009.10.007.
Microfluidic reactors exhibit intrinsic advantages of reduced chemical consumption, safety, high surface-area-to-volume ratios, and improved control over mass and heat transfer superior to the macroscopic reaction setting. In contract to a continuous-flow microfluidic system composed of only a microchannel network, an integrated microfluidic system represents a scalable integration of a microchannel network with functional microfluidic modules, thus enabling the execution and automation of complicated chemical reactions in a single device. In this review, we summarize recent progresses on the development of integrated microfluidics-based chemical reactors for (i) parallel screening of in situ click chemistry libraries, (ii) multistep synthesis of radiolabeled imaging probes for positron emission tomography (PET), (iii) sequential preparation of individually addressable conducting polymer nanowire (CPNW), and (iv) solid-phase synthesis of DNA oligonucleotides. These proof-of-principle demonstrations validate the feasibility and set a solid foundation for exploring a broad application of the integrated microfluidic system.
微流控反应器具有化学试剂消耗少、安全性高、表面积与体积比大以及传质传热控制优于宏观反应装置等固有优势。与仅由微通道网络组成的连续流微流控系统不同，集成微流控系统代表了微通道网络与功能性微流控模块的可扩展集成，从而能够在单个设备中执行和自动化复杂的化学反应。在本综述中，我们总结了基于集成微流控的化学反应器的最新进展，这些反应器用于：（i）原位点击化学文库的平行筛选；（ii）用于正电子发射断层扫描（PET）的放射性标记成像探针的多步合成；（iii）可单独寻址的导电聚合物纳米线（CPNW）的顺序制备；以及（iv）DNA寡核苷酸的固相合成。这些原理验证演示验证了可行性，并为探索集成微流控系统的广泛应用奠定了坚实基础。
