Komiyama Maki, Takanabe Rieko, Ono Koh, Shimada Sayaka, Wada Hiromichi, Yamakage Hajime, Satoh-Asahara Noriko, Morimoto Tatsuya, Shimatsu Akira, Takahashi Yuko, Hasegawa Koji
1 Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
2 Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
J Int Med Res. 2018 Mar;46(3):965-974. doi: 10.1177/0300060517723415. Epub 2017 Nov 3.
Objective The expression level of monocyte chemoattractant protein-1 (MCP-1) is increased in atherosclerotic regions, inducing monocyte migration to the blood vessel wall. Although the serum MCP-1 concentration is higher in patients with than without cardiovascular disease, the precise correlations between the serum MCP-1 concentration and factors associated with smoking and atherosclerosis are unknown. Methods The serum MCP-1 concentration was measured using an enzyme-linked immunosorbent assay in 207 consecutive smokers who visited our smoking cessation clinic. Results Sex-adjusted analysis of smokers revealed that the MCP-1 concentration was positively correlated with age ( β = 0.311), smoking duration ( β = 0.342), systolic blood pressure ( β = 0.225), and diastolic blood pressure ( β = 0.137) but not with the body mass index. Multivariate regression analysis showed that smoking duration and systolic blood pressure were independent determinants of the MCP-1 concentration. Conclusions The MCP-1 concentration was positively correlated with blood pressure among smokers. Long-term smokers with high blood pressure may be more susceptible to plaque rupture at atherosclerotic lesion sites.
目的 单核细胞趋化蛋白-1（MCP-1）在动脉粥样硬化区域的表达水平升高，可诱导单核细胞向血管壁迁移。虽然心血管疾病患者的血清MCP-1浓度高于无心血管疾病者，但血清MCP-1浓度与吸烟及动脉粥样硬化相关因素之间的确切关联尚不清楚。方法 采用酶联免疫吸附测定法，对连续就诊于我们戒烟门诊的207名吸烟者的血清MCP-1浓度进行检测。结果 对吸烟者进行性别校正分析发现，MCP-1浓度与年龄（β = 0.311）、吸烟时长（β = 0.342）、收缩压（β = 0.225）和舒张压（β = 0.137）呈正相关，与体重指数无关。多因素回归分析显示，吸烟时长和收缩压是MCP-1浓度的独立决定因素。结论 在吸烟者中，MCP-1浓度与血压呈正相关。患有高血压的长期吸烟者可能更容易在动脉粥样硬化病变部位发生斑块破裂。
