Post Graduation Program in Veterinary Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Graduation Program in Veterinary Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
J Feline Med Surg. 2023 Feb;25(2):1098612X221149384. doi: 10.1177/1098612X221149384.
The aim of this study was to evaluate the influence of a preappointment oral dose of gabapentin on the neurological examination of cats.
A prospective, randomized and blinded clinical trial was conducted in 35 client-owned healthy cats. Cats were scheduled for two appointments and randomly assigned to receive either a placebo or a 100 mg gabapentin capsule prior to the second veterinary visit. A neurological examination was performed during each visit, and the results were compared between groups. Normal/abnormal response rates for each test were based on the number of cats that allowed the test to be performed.
Gabapentin was administered to 17 cats. Gait and postural reactions were significantly affected in the gabapentin group. Comparing the gabapentin with the placebo groups, proprioceptive ataxia was identified in 4/17 (23.5%) vs 0/18 cats ( = 0.0288); paw placement deficits were seen in 10/11 (90.9%) vs 1/4 (25%) cats; table tactile placement deficits were identified in 13/17 (76.5%) vs 0/18 cats ( <0.0001); hopping deficits were seen in 5/17 (29.4%) vs 0/16 cats ( = 0.0185); and abnormalities on wheelbarrowing and extensor postural thrust were reported in 5/17 (29.4%) vs 0/18 cats ( = 0.0129). These results had no correlation with age or dose/kg received. No significant difference was noted in the assessment of level and content of consciousness, posture, cranial nerves and spinal nerves. No significant differences were noted in test compliance or examination duration.
Gabapentin significantly altered gait analyses and postural reactions in this group of healthy cats. The administration of gabapentin could lead to false-positive results and, possibly, an incorrect identification of neurological lesions. In contrast, gabapentin did not impair the assessment of cranial nerves and spinal reflexes, which can be assessed in patients receiving the drug.
本研究旨在评估猫术前口服加巴喷丁对神经检查的影响。
这是一项前瞻性、随机、双盲临床试验，纳入了 35 只患宠猫。这些猫被安排了两次就诊，并在第二次就诊前随机分为接受安慰剂或 100mg 加巴喷丁胶囊组。每次就诊时都进行神经检查，并比较组间结果。每项检查的正常/异常反应率是基于允许进行检查的猫的数量。
17 只猫接受了加巴喷丁治疗。加巴喷丁组的步态和姿势反射明显受到影响。与安慰剂组相比，加巴喷丁组的本体感觉性共济失调为 4/17（23.5%）比 0/18 只猫（=0.0288）；爪放置缺陷为 10/11（90.9%）比 1/4（25%）只猫；桌子触觉放置缺陷为 13/17（76.5%）比 0/18 只猫（<0.0001）；跳跃缺陷为 5/17（29.4%）比 0/16 只猫（=0.0185）；轮式推车和伸肌姿势推力异常在 5/17（29.4%）只猫中报告，而在 0/18 只猫中报告（=0.0129）。这些结果与年龄或剂量/体重无关。在意识水平和内容、姿势、颅神经和脊神经的评估中，没有发现显著差异。在测试依从性或检查持续时间方面也没有显著差异。
加巴喷丁在这群健康猫中显著改变了步态分析和姿势反射。加巴喷丁的使用可能导致假阳性结果，并可能导致对神经病变的错误识别。相比之下，加巴喷丁并未损害接受该药物治疗的患者的颅神经和脊髓反射评估。
