Meng Qingshuo, Meng Jia, Ran Wei, Su Jinghan, Yang Yuguang, Zhang Pengcheng, Li Yaping
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
Chem Commun (Camb). 2017 Nov 16;53(92):12438-12441. doi: 10.1039/c7cc07465d.
We report a photochemical reaction-induced antagonism between the photodynamic agent (PS) and anti-cancer drugs during combined therapy. The annihilation of singlet oxygen and alkene-containing drugs into inactive drug hydroperoxides is responsible for the antagonism, and results in decreased efficacy against several cancer cell lines. Experimental and simulation results reveal that the annihilation abates with increasing distance between the PS and drugs via confining the PS and drugs into separated vehicles. As a result, antagonism can be switched to synergism in treating both drug sensitive and resistant cancer cells.
我们报道了联合治疗期间光动力剂（PS）与抗癌药物之间的光化学反应诱导的拮抗作用。单线态氧与含烯烃药物湮灭生成无活性的药物氢过氧化物是导致这种拮抗作用的原因，并且导致对几种癌细胞系的疗效降低。实验和模拟结果表明，通过将PS和药物限制在分离的载体中，随着PS与药物之间距离的增加，湮灭作用减弱。因此，在治疗药物敏感和耐药癌细胞时，拮抗作用可以转变为协同作用。
