利用¹⁷O核磁共振研究弗瑞德白血病细胞分化过程中的水渗透性变化。
Water permeability changes studied by 17O nuclear magnetic resonance during differentiation of Friend leukemia cells.
作者信息
Haran N, Malik Z, Lapidot A
出版信息
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3363-6. doi: 10.1073/pnas.76.7.3363.
Water permeability of Friend leukemia cells was studied by 17O nuclear magnetic resonance during differentiation induced by dimethyl sulfoxide (Me2SO). While in noninduced cells water permeability was essentially constant during the growth period, in the Me2SO-induced cells there were two distinct periods at which the water permeability was increased by at least an order of magnitude. These periods correspond to approximately one doubling time and 6 days of growth. This change in water permeability is not due to direct interaction of Me2SO with the membrane but must be ascribed to structural changes in the membrane during the course of differentiation.
利用17O核磁共振技术研究了二甲亚砜（Me2SO）诱导分化过程中弗瑞德白血病细胞的水通透性。在未诱导的细胞中，水通透性在生长期间基本保持恒定，而在Me2SO诱导的细胞中，有两个不同的时期，水通透性至少增加了一个数量级。这些时期分别对应大约一个倍增时间和6天的生长时间。水通透性的这种变化并非由于Me2SO与细胞膜的直接相互作用，而必定归因于分化过程中细胞膜的结构变化。
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