Tabriz University of Medical Sciences, Tabriz, Iran.
Dezful University of Medical Sciences, Dezful, Iran.
Int J Biol Macromol. 2018 Feb;107(Pt B):2436-2449. doi: 10.1016/j.ijbiomac.2017.10.128. Epub 2017 Oct 31.
The main aim of the present study was to design pH-sensitive bionanocomposite hydrogel beads based on CMC and HNT-AT nanohybrid and evaluate whether prepared bionanocomposite beads have the potential to be used in drug delivery applications. Atenolol (AT), as a model drug, was incorporated into the lumen of HA nanotubes via the co-precipitation technique. HNT/AT nanohybrid and CMC/HNT-AT beads were characterized via XRD, SEM, TGA, and FT-IR techniques. Drug loading and encapsulation efficiency was found to be high for CMC/HNT3 beads. Moreover, the swelling and drug release properties of the prepared CMC/HA-AT beads were investigated, and showed a pH sensitive swelling behavior with maximum its content at pH 6.8. Also, it was found that the swelling ratio of CMC/HNT beads was lower than that of pristine CMC beads. Drug release behavior of CMC/HNT-AT bionanocomposite hydrogel beads were investigated. A more sustained and controlled drug releases were observed for CMC/HNT-AT beads.
本研究的主要目的是设计基于 CMC 和 HNT-AT 纳米杂化的 pH 敏感仿生复合水凝胶珠，并评估所制备的仿生复合水凝胶珠是否有可能用于药物输送应用。阿替洛尔（AT）作为模型药物，通过共沉淀技术被掺入 HA 纳米管的内腔中。通过 XRD、SEM、TGA 和 FT-IR 技术对 HNT/AT 纳米杂化和 CMC/HNT-AT 珠进行了表征。发现 CMC/HNT3 珠具有较高的载药量和包封效率。此外，还研究了制备的 CMC/HA-AT 珠的溶胀和药物释放性能，结果表明其在 pH 6.8 时具有 pH 敏感的溶胀行为，最大含量。此外，发现 CMC/HNT 珠的溶胀率低于原 CMC 珠的溶胀率。研究了 CMC/HNT-AT 仿生复合水凝胶珠的药物释放行为。对于 CMC/HNT-AT 珠，观察到更持续和受控的药物释放。
