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蒙脱石-法莫替丁/壳聚糖生物纳米复合水凝胶作为一种黏膜黏附/胃滞留给药系统

Montmorillonite-Famotidine/Chitosan Bio-nanocomposite Hydrogels as a Mucoadhesive/Gastroretentive Drug Delivery System.

作者信息

Farhadnejad Hassan, Mortazavi Seyed Alireza, Jamshidfar Sanaz, Rakhshani Amir, Motasadizadeh Hamidreza, Fatahi Yousef, Mahdieh Athar, Darbasizadeh Behzad

机构信息

Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Research and Development Department, Varian Pharmed Pharmaceutical Company, Tehran, Iran.

出版信息

Iran J Pharm Res. 2022 May 12;21(1):e127035. doi: 10.5812/ijpr-127035. eCollection 2022 Dec.

DOI:10.5812/ijpr-127035
PMID:36060919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9420228/
Abstract

The main purpose of the present study was to fabricate mucoadhesive bio-nanocomposite hydrogels to prolong the drug retention time in the stomach. In these bio-nanocomposite hydrogels, chitosan (CH) was used as a bioadhesive matrix, montmorillonite (MMT) was applied to modulate the release rate, and tripolyphosphate (TPP) was the cross-linking agent. The test samples were analyzed via different methods such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). Drug incorporation efficacy and mucoadhesive strength of these nanocomposite hydrogel beads were studied. Swelling and in vitro drug release behaviors of these bio-nanocomposite hydrogels were evaluated in simulated gastric fluid (SGF; pH 1.2). The optimized MMT-famotidine (FMT)/CH bio-nanocomposite hydrogels displayed a controllable and sustainable drug release profile with suitable mucoadhesion and prolonged retention time in the stomach. Thus, the results demonstrated that the fabricated mucoadhesive bio-nanocomposite hydrogels could remarkably increase the therapeutic efficacy and bioavailability of FMT by the oral route.

摘要

本研究的主要目的是制备粘膜粘附性生物纳米复合水凝胶，以延长药物在胃中的滞留时间。在这些生物纳米复合水凝胶中，壳聚糖（CH）用作生物粘附基质，蒙脱石（MMT）用于调节释放速率，三聚磷酸钠（TPP）为交联剂。通过不同方法对测试样品进行分析，如X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）、热重分析（TGA）和扫描电子显微镜（SEM）。研究了这些纳米复合水凝胶珠的药物包封率和粘膜粘附强度。在模拟胃液（SGF；pH 1.2）中评估了这些生物纳米复合水凝胶的溶胀和体外药物释放行为。优化后的MMT-法莫替丁（FMT）/CH生物纳米复合水凝胶呈现出可控且可持续的药物释放曲线，具有合适的粘膜粘附性和在胃中的延长滞留时间。因此，结果表明所制备的粘膜粘附性生物纳米复合水凝胶可通过口服途径显著提高FMT的治疗效果和生物利用度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/8c64fd35deef/ijpr-21-1-127035-i003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/b3de6e51956e/ijpr-21-1-127035-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/211bc5c950a9/ijpr-21-1-127035-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/a00885b05053/ijpr-21-1-127035-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/d2bf2bcc90dc/ijpr-21-1-127035-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/360a3528156a/ijpr-21-1-127035-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/6a4f00f12f57/ijpr-21-1-127035-i001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/ed2bd6cdcefb/ijpr-21-1-127035-i002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/8c64fd35deef/ijpr-21-1-127035-i003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/b3de6e51956e/ijpr-21-1-127035-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/211bc5c950a9/ijpr-21-1-127035-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/a00885b05053/ijpr-21-1-127035-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/d2bf2bcc90dc/ijpr-21-1-127035-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/360a3528156a/ijpr-21-1-127035-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/6a4f00f12f57/ijpr-21-1-127035-i001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/ed2bd6cdcefb/ijpr-21-1-127035-i002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0c4/9420228/8c64fd35deef/ijpr-21-1-127035-i003.jpg

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