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布洛芬-介孔羟基磷灰石纳米杂化物作为一种缓释药物递送系统的简便合成与表征

Facile Synthesis and Characterization of Ibuprofen-mesoporous Hydroxyapatite Nanohybrid as a Sustained Drug Delivery System.

作者信息

Namazi Zahra, Jafarzadeh Kashi Tahereh Sadat, Erfan Mohammad, Najafi Farhood, Bakhtiari Leila, Ghodsi Seyed Rohola, Farhadnejad Hassan

机构信息

Department of Dental Biomaterials, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Iranian Tissue Bank and Research Center, Imam Khomeini Medical Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Iran J Pharm Res. 2019 Summer;18(3):1196-1211. doi: 10.22037/ijpr.2019.1100769.

DOI:10.22037/ijpr.2019.1100769
PMID:32641932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6934965/
Abstract

The present study deals with the fabrication of ibuprofen-mesoporous hydroxyapatite (IBU-MHA) particles via the incorporation of ibuprofen (IBU)-as a nonsteroidal anti-inflammatory drug-into mesoporous hydroxyapatite nanoparticles (MHANPs) using an impregnation process, as a novel drug delivery device. MHANPs were synthesized by a self-assembly process using cetyltrimethylammonium bromide (CTAB) as a cationic surfactant and 1-dodecanethiol as a pore expander under basic condition. The focus of the present study was to optimize the incorporation of IBU molecules into MHANPs under different loading conditions. The synthesized MHANPs and IBU-MHA particles were confirmed by X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FTIR), brunauer-emmett-teller (BET), transmission electron microscopy (TEM), and thermal analysis (TGA). Drug loading (DL) efficiency of IBU-MHA particles was determined by ultraviolet-visible (UV-Vis) spectroscopy, and indicated that the optimized IBU-MHA particles with high DL (34.5%) can be obtained at an IBU/ MHANPs ratio of 35/50 (mg/mg), impregnation period of 24 h, and temperature of 40 °C using ethanol as solvent. drug release test was carried out to prove the efficiency of IBU-MHA particles as a sustained drug delivery system. A more sustained and controlled drug release was observed for this particles, indicating that it may be have good potential as drug reservoirs for local drug release.

摘要

本研究通过浸渍法将作为非甾体抗炎药的布洛芬（IBU）掺入介孔羟基磷灰石纳米颗粒（MHANPs）中，制备布洛芬-介孔羟基磷灰石（IBU-MHA）颗粒，作为一种新型药物递送装置。在碱性条件下，以十六烷基三甲基溴化铵（CTAB）为阳离子表面活性剂、1-十二烷硫醇为扩孔剂，通过自组装过程合成了MHANPs。本研究的重点是在不同负载条件下优化IBU分子掺入MHANPs的过程。通过X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）、布鲁诺尔-埃米特-泰勒（BET）法、透射电子显微镜（TEM）和热分析（TGA）对合成的MHANPs和IBU-MHA颗粒进行了表征。采用紫外可见（UV-Vis）光谱法测定了IBU-MHA颗粒的载药（DL）效率，结果表明，以乙醇为溶剂，在IBU/MHANPs比例为35/50（mg/mg）、浸渍时间为24 h、温度为40℃的条件下，可以获得载药率高（34.5%）的优化IBU-MHA颗粒。进行了药物释放试验，以证明IBU-MHA颗粒作为缓释药物递送系统的有效性。观察到该颗粒具有更持续和可控的药物释放，表明其作为局部药物释放的药物储库可能具有良好的潜力。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfd/6934965/17d5441548fb/ijpr-18-1196-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfd/6934965/78662c6712f2/ijpr-18-1196-g009.jpg
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