Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853, USA.
Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Curr Rheumatol Rep. 2017 Nov 4;19(12):77. doi: 10.1007/s11926-017-0705-1.
Changes in the constituents and activity of the microbiome have been associated with a number of conditions linked to bone and joint disease. This review concentrates on ways in which the microbiome is known to influence osteoarthritis and osteoporosis.
Animal studies have demonstrated that changes in the microbiome can mediate the effects of obesity on cartilage degeneration. Additionally, the microbiome influences the amount of the bone (bone quantity), as well as bone tissue material properties (bone quality). Early clinical findings support the effects of the microbiome on osteoporosis and osteoarthritis. Although animal studies implicate the microbiome in the development of bone and joint disease, available results are limited and can be conflicting. Further investigation of the mechanisms linking from changes in the microbiome to alterations in the bones and joints are necessary.
微生物组的组成和活性的变化与许多与骨骼和关节疾病相关的疾病有关。本综述集中讨论了微生物组影响骨关节炎和骨质疏松症的方式。
动物研究表明，微生物组的变化可以调节肥胖对软骨退化的影响。此外，微生物组还会影响骨骼的数量（骨量）以及骨骼组织的材料特性（骨质量）。早期的临床发现支持微生物组对骨质疏松症和骨关节炎的影响。尽管动物研究表明微生物组与骨骼和关节疾病的发生有关，但现有结果有限且相互矛盾。有必要进一步研究将微生物组的变化与骨骼和关节的变化联系起来的机制。
