The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kgs, Lyngby, Denmark.
The Novo Nordisk Foundation Center for Biosustainability, Department of Chemical & Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE412 96 Gothenburg, Sweden.
Curr Opin Biotechnol. 2018 Apr;50:39-46. doi: 10.1016/j.copbio.2017.10.002. Epub 2017 Nov 1.
Traditional oleochemical industry chemically processes animal fats and plant oils to produce detergents, lubricants, biodiesel, plastics, coatings, and other products. Biotechnology offers an alternative process, where the same oleochemicals can be produced from abundant biomass feedstocks using microbial catalysis. This review summarizes the recent advances in the engineering of microbial metabolism for production of fatty acid-derived products. We highlight the efforts in engineering the central carbon metabolism, redox metabolism, controlling the chain length of the products, and obtaining metabolites with different functionalities. The prospects of commercializing microbial oleochemicals are also discussed.
传统的油脂化工行业通过化学方法处理动物脂肪和植物油，以生产洗涤剂、润滑剂、生物柴油、塑料、涂料和其他产品。生物技术提供了一种替代方法，即可以使用微生物催化从丰富的生物质原料中生产相同的油脂化学品。本综述总结了微生物代谢工程在脂肪酸衍生产品生产方面的最新进展。我们重点介绍了工程化中央碳代谢、氧化还原代谢、控制产物链长以及获得具有不同功能的代谢物的努力。还讨论了微生物油脂化学品的商业化前景。
