Joseph J P, Grierson I, Hitchings R A
Pathology Department, Institute of Ophthalmology, London, England.
Arch Ophthalmol. 1989 Jan;107(1):69-74. doi: 10.1001/archopht.1989.01070010071030.
The chemoattractant activity for ocular fibroblasts of the aqueous humor of patients undergoing glaucoma surgery was evaluated in 48-well microchemotaxis chambers and compared with control specimens from patients undergoing cataract extractions. All specimens were chemoattractant, but those from patients who had previously undergone glaucoma surgery that had failed were of significantly greater activity than the controls'. This chemoattractant activity is primarily chemotactic. It consists of heat-stable and heat-labile components. The predisposition of a patient to sustain failed glaucoma drainage surgery may be related to the chemoattractant activity of his aqueous humor, since strongly chemoattractant aqueous humor may encourage fibrosis at the operation site.
在48孔微量趋化性实验小室中评估了青光眼手术患者房水对眼成纤维细胞的趋化活性，并与白内障摘除患者的对照样本进行了比较。所有样本均具有趋化活性，但先前接受过失败的青光眼手术患者的样本活性明显高于对照组。这种趋化活性主要是趋化性的。它由热稳定和热不稳定成分组成。患者青光眼引流手术失败的易感性可能与其房水的趋化活性有关，因为具有强烈趋化活性的房水可能会促进手术部位的纤维化。
