Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, Boutalamine, 52000 Errachidia, Morocco.
J Integr Med. 2017 Nov;15(6):476-482. doi: 10.1016/S2095-4964(17)60361-3.
Tamarix articulata Vahl. (Tamaricaceae) is a medicinal plant commonly used in Morocco for the treatment of diabetes mellitus and cardiovascular diseases. The objective of this study was to evaluate the hypolipidemic activity of aqueous extract of T. articulata in normal and streptozotocin (STZ)-induced diabetic rats. Phytochemical analysis as well as determination of polyphenol and flavonoid contents in the aqueous extract of T. articulata was performed.
The effects of oral administration of aqueous extract of T. articulata (5 mg/kg) on the plasma total cholesterol, triglyceride and high-density lipoprotein cholesterol (HDL-c) concentrations were measured in both normal and STZ-induced diabetic rats. Total phenolic content of the aqueous extract was determined by Folin-Ciocalteu method. In addition, determination of flavonoid content was performed using colorimetric AlCl3 method.
A single oral administration in diabetic rats induced a significant increase in the HDL-c concentration after 6 h of treatment with T. articulata (5 mg/kg). The results also demonstrated that the aqueous extract of T. articulata produced a significant decrease of serum total cholesterol after repeated oral administration in diabetic rats (P < 0.01). The total polyphenol and flavonoid contents of T. articulata aqueous extract were equal to 102.50 mg of gallic acid equivalent per gram of extract and 54.83 mg of quercetin equivalent per gram of extract, respectively.
According to preliminary phytochemical screening of the aerial part of T. articulata, several classes of chemicals have been found, such as polyphenols, flavonoids, tannins, cyanidins (flavones, catechols), mucilage, sesquiterpenes, terpenoids and carbohydrates. In conclusion, T. articulata exhibits a hypolipidemic effect in diabetic rats and its beneficial role as hypolipidemic agent should be evaluated in clinical studies.
柽柳（柽柳科）是一种药用植物，在摩洛哥常用于治疗糖尿病和心血管疾病。本研究旨在评估柽柳水提物对正常和链脲佐菌素（STZ）诱导的糖尿病大鼠的降血脂活性。对柽柳水提物进行了植物化学分析以及多酚和类黄酮含量的测定。
在正常和 STZ 诱导的糖尿病大鼠中，测量口服柽柳水提物（5mg/kg）对血浆总胆固醇、甘油三酯和高密度脂蛋白胆固醇（HDL-c）浓度的影响。采用福林-肖卡法测定水提物中总酚含量。此外，采用比色法 AlCl3 法测定黄酮类化合物的含量。
单次口服柽柳（5mg/kg）可在治疗后 6 小时显著增加糖尿病大鼠的 HDL-c 浓度。结果还表明，柽柳水提物重复口服可显著降低糖尿病大鼠的血清总胆固醇（P<0.01）。柽柳水提物的总多酚和类黄酮含量分别为 102.50mg 没食子酸当量/克提取物和 54.83mg 槲皮素当量/克提取物。
根据柽柳地上部分的初步植物化学筛选，发现了几类化学物质，如多酚、类黄酮、单宁、氰定（类黄酮、儿茶素）、黏液、倍半萜、萜类化合物和碳水化合物。综上所述，柽柳在糖尿病大鼠中表现出降血脂作用，其作为降血脂剂的有益作用应在临床研究中进行评估。
