咖啡、酒精、吸烟与胰腺癌：一项病例对照研究。

Coffee, alcohol, smoking and cancer of the pancreas: a case-control study.

作者信息

Clavel F, Benhamou E, Auquier A, Tarayre M, Flamant R

机构信息

Unité de Recherches en Epidémiologie des Cancers de l'INSERM (U287), Institut Gustave Roussy, Villejuif, France.

出版信息

Int J Cancer. 1989 Jan 15;43(1):17-21. doi: 10.1002/ijc.2910430105.

DOI:10.1002/ijc.2910430105

PMID:2910828

Abstract

A hospital case control study on smoking, alcohol and coffee consumption as risk factors for pancreatic cancer, in which 161 cases were matched to 268 control patients, was conducted in France between 1982 and 1985. The results showed no association between tobacco or alcohol consumption and cancer of the pancreas, whereas coffee consumption was associated with an increased risk [OR of 2 or more cups per day vs. less: 2.27 (1.11-4.64) and 1.45 (0.82-2.55) among females and males respectively]. A dose-response relationship was observed with coffee consumption in both sexes, stronger among females than among males: the linear increase estimates were 2.00 (1.22-3.29) and 1.32 (0.91-1.92) respectively. No interaction was found between coffee and tobacco, whereas the effect of coffee appeared to be limited to non-drinkers of alcohol.

摘要

1982年至1985年期间，在法国进行了一项关于吸烟、饮酒和咖啡消费作为胰腺癌风险因素的医院病例对照研究，其中161例病例与268例对照患者进行了匹配。结果显示，吸烟或饮酒与胰腺癌之间没有关联，而咖啡消费与风险增加有关[女性和男性每天饮用2杯或更多杯咖啡与较少杯数相比的比值比分别为：2.27(1.11 - 4.64)和1.45(0.82 - 2.55)]。在两性中均观察到咖啡消费与剂量反应关系，女性比男性更强：线性增加估计值分别为2.00(1.22 - 3.29)和1.32(0.91 - 1.92)。未发现咖啡与烟草之间存在相互作用，而咖啡的影响似乎仅限于不饮酒者。