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电子烟气溶胶中的醛水平:一项复制研究和使用新一代设备的结果。

Aldehyde levels in e-cigarette aerosol: Findings from a replication study and from use of a new-generation device.

机构信息

Department of Cardiology, Onassis Cardiac Surgery Center, Sygrou 356, Kallithea 17674, Greece; Department of Pharmacy, University of Patras, Rio 26500, Greece.

Department of Chemistry, The Pennsylvania State University Brandywine, 25 Yearsley Mill Road, Media, PA 19063, USA.

出版信息

Food Chem Toxicol. 2018 Jan;111:64-70. doi: 10.1016/j.fct.2017.11.002. Epub 2017 Nov 3.

Abstract

PURPOSE

A recent study identified high aldehyde emissions from e-cigarettes (ECs), that when converted to reasonable daily human EC liquid consumption, 5 g/day, gave formaldehyde exposure equivalent to 604-3257 tobacco cigarettes. We replicated this study and also tested a new-generation atomizer under verified realistic (no dry puff) conditions.

DESIGN

CE4v2 atomizers were tested at 3.8 V and 4.8 V, and a Nautilus Mini atomizer was tested at 9.0 W and 13.5 W. All measurements were performed in a laboratory ISO-accredited for EC aerosol collection and aldehyde measurements.

RESULTS

CE4v2 generated dry puffs at both voltage settings. Formaldehyde levels were >10-fold lower, acetaldehyde 6-9-fold lower and acrolein 16-26-fold lower than reported in the previous study. Nautilus Mini did not generate dry puffs, and minimal aldehydes were emitted despite >100% higher aerosol production per puff compared to CE4v2 (formaldehyde: 16.7 and 16.5 μg/g; acetaldehyde: 9.6 and 10.3 μg/g; acrolein: 8.6 and 11.7 μg/g at 9.0 W and 13.5 W, respectively). EC liquid consumption of 5 g/day reduces aldehyde exposure by 94.4-99.8% compared to smoking 20 tobacco cigarettes.

CONCLUSION

Checking for dry puffs is essential for EC emission testing. Under realistic conditions, new-generation ECs emit minimal aldehydes/g liquid at both low and high power. Validated methods should be used when analyzing EC aerosol.

摘要

目的

最近的一项研究发现电子烟(EC)会产生大量的醛类物质,当这些醛类物质转化为合理的每日人类 EC 液体摄入量,即 5 克/天时,其甲醛暴露量相当于 604-3257 支香烟。我们复制了这项研究,并在经过验证的现实(无干吸)条件下测试了一种新一代雾化器。

设计

在 3.8V 和 4.8V 下测试了 CE4v2 雾化器,并在 9.0W 和 13.5W 下测试了 Nautilus Mini 雾化器。所有测量均在一个经过 ISO 认证的实验室中进行,该实验室可用于收集 EC 气溶胶和测量醛类物质。

结果

CE4v2 在两种电压设置下都会产生干吸。甲醛水平比之前的研究报告低 10 倍以上,乙醛低 6-9 倍,丙烯醛低 16-26 倍。Nautilus Mini 不会产生干吸,尽管与 CE4v2 相比,每口烟雾产生的气溶胶量高出 100%以上,但排放的醛类物质却很少(甲醛:9.0W 和 13.5W 时分别为 16.7 和 16.5μg/g;乙醛:9.6 和 10.3μg/g;丙烯醛:8.6 和 11.7μg/g)。与吸 20 支香烟相比,每天消耗 5 克 EC 液体可将醛类物质暴露量减少 94.4-99.8%。

结论

检查是否有干吸对于 EC 排放测试至关重要。在现实条件下,新一代 EC 在低功率和高功率下每克液体的醛类排放量都很小。在分析 EC 气溶胶时应使用经过验证的方法。

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