Department of Biochemistry and Clinical Laboratory Diagnostics, Medical State University, Butlerov Street 49, Kazan, Republic of Tatarstan, Russia.
Laboratory of Immunology and the Development of Allergens, Mycology Research Laboratory, Research Institute of Epidemiology and Microbiology, Big Red Street 67, Kazan, Republic of Tatarstan 420015, Russia.
J Immunol Res. 2017;2017:3054217. doi: 10.1155/2017/3054217. Epub 2017 Oct 4.
Allergic rhinitis (AR) is especially prevalent among the population of large cities. Immunologically, the airway epithelium is a region where the population of allergen-presenting cells concentrates. These cells actively express a group of receptors of the innate immune system. A specific cytokine profile is its representation. The study was aimed at evaluating the cytokine profile in patients with seasonal and perennial allergic rhinitis. The cytokine profile of nasal secretion and blood serum of 44 patients with AR was studied. 24 of them had seasonal allergic rhinitis (SAR), and 20 patients suffered from perennial allergic rhinitis (PAR). The patients' age ranged from 4 to 60 years. It was determined in our study that the activation of the GM-CSF production retained in patients with PAR sensitized to mite allergen components (). There was a higher production profile of TNF- and TSLP in nasal secretion in the patients with perennial allergic rhinitis and additional high sensitization to SEs. Sensitization to mold fungal allergen components significantly increases in patients with seasonal allergic rhinitis. They demonstrated high level of sensitization to the component m3. Thus, along with other clinical trials, the study performed would clarify some aspects of molecular pathogenesis of human allergic rhinitis.
变应性鼻炎（AR）在大城市人群中尤为普遍。从免疫学角度来看，气道上皮是过敏原呈递细胞集中的区域。这些细胞积极表达一组先天免疫系统的受体。其代表性的是特定的细胞因子谱。本研究旨在评估季节性和常年性变应性鼻炎患者的细胞因子谱。研究了 44 例 AR 患者的鼻分泌物和血清细胞因子谱。其中 24 例为季节性变应性鼻炎（SAR），20 例为常年性变应性鼻炎（PAR）。患者年龄 4-60 岁。我们的研究表明，对螨过敏原成分敏感的 PAR 患者保留的 GM-CSF 产生的激活（）。在常年性变应性鼻炎患者的鼻分泌物中，TNF-和 TSLP 的产生谱更高，并且对 SEs 的额外高敏感性。对霉菌真菌过敏原成分的敏感性在季节性变应性鼻炎患者中显著增加。他们对成分 m3 表现出高敏性。因此，与其他临床试验一起，本研究将阐明人类变应性鼻炎分子发病机制的一些方面。
